化學(xué)生物學(xué)-全文預(yù)覽
【正文】 NA利用 Nglycosidic bond將氮鹼(nitrogen base)與核醣相結(jié)合，二個(gè)相鄰核苷則是用 磷酸雙酯鍵 (phosphodiester bond) 相結(jié)合。細(xì)胞分裂為二後，每個(gè)子細(xì)胞之胞漿膜亦已組妥為磷脂雙層。 細(xì)胞膜的功能 a. 邊界 (boundary) b. 區(qū)位化 (partmentation) c. 通透 (permeability) d. 監(jiān)測(cè)內(nèi)外訊息 (innerouter signal transduction) e. 細(xì)胞間黏附與交互作用 (adhesion and interaction) 18 Phospholipids: amphipathic molecules (membrane position) 19 Biomembranes: phospholipid (PL) bilayers Amphipathic 20 Biomembranes: Phospholipid bilayer 21 細(xì)胞膜 (III) a. 邊界 b. 區(qū)位化 c. 通透 d. 監(jiān)測(cè)內(nèi)外訊息 e. 細(xì)胞間黏附與交互作用 Biomembranes Network? Fiber like? Gate type? 22 Fig. 214. Hierarchical nature of cellular structures and their assembly 1. Small molecules 2. Macromolecules 3. Supramolecular structures 4. Subcellular anelles 5. Cell 23 Cell architecture (I) Level 1: Small anic molecules Level 2: Macromolecules Level 3: Supramolecular structures Level 4: Subcellular anelles Level 5: The cell 24 The synthesis of biological macromolecules 25 生物大分子 (biological macromolecules) 合成原則 (I) 生物大分子種類及結(jié)構(gòu)變化雖多，但其合成原則大致都是採(cǎi)用小分子建材 (building blocks) 方式組合 (I) Synthesis by polymerization of monomers using same, stable covalent bonding repeatedly 26 生物大分子合成原則 (II) a. 勝肽 (peptides)與蛋白質(zhì) (proteins) 是由 20種的胺基酸所組成的。碳可產(chǎn)生多鍵結(jié) 的安定共價(jià)鍵 (covalent bonds)，以及碳可呈現(xiàn) SP3 (正四面體 ) (tetrahedron) 和 SP2 (平面 ) 之混成軌域，造成含碳化合物立體構(gòu)形多變化。細(xì)胞運(yùn)作的化學(xué)原理並無(wú)因控管生命現(xiàn)象而有不同?；瘜W(xué) 生物學(xué) Chemical Biology 1 The course a. Lecture (2 hours per week) (3:30— 5:20 PM, Thursday) b. Three instructors 1. Shiao (VGHTaipei) (5) 2. Lin (6) 3. Lee (4) About the course evaluation 蕭明熙 臺(tái)北榮民總醫(yī)院 教學(xué)研究部 Tel: (02)28712121 Ext. 3363 2 What is chemical biology? To understand the biological functions at the molecular and cellular levels by using the chemical tools (including chemical principles and chemicals as tools) a. DNA and RNA b.
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