分子生物物理學-全文預覽
【正文】 by Degrado, USAHelical+structure?helicesthisinii+3Standard 310 helixProlineand)hydrogenhelicalnearlyinthehelixstandardsomewhatareahelicesprotein?the dipoles of hydrogen bonding backbone atoms are in near perfect alignment. the radius ( angstrom)of the helix allows for favorable van der Waals interactions across the helical axis side chains are well staggered minimizing steric interference? CO group toward carboxyl terminus? NH group toward amide terminus? Hbond, i(i+4)? Side chain: i(i+3)。abundant, . the ahelix has a rise per residue of 197。197。41structureahelixstructure[n] is the number of residues per helical turn[r] is the helical rise per residue (nm)[p] is the helical pitch (nm). Hbond Atoms in Hbond loopradius i, i+4 13 310 i, i+3 10 ? i, i+5 16 Parametershelix?helix ? ? n r P 57 47 310 49 26 ? 57 7 Paral? 119 +113 Antiparal ? 139 +135 Parametersnm Hbond definition, Hbond location O….H XHydrogenpotential6Relation with Energy and distance Van2dipoledipole randatom()phi(197。StructurePeptide bondBackboneSide chain Amine/N terminusCarboxyl/C terminus groups)Nonpolar G,A,V,L,I。acidMajorzwitterionstructureMinorby Linderstr248。StructureHierarchysupersecondarySTRUCTURE 1965年中國在世界上首次用化學方法人工合成的蛋白質 － 牛胰島素SecondaryinBiophysics分子生物物理學分子生物物理學分子水平分子水平結構結構 功能功能研究生物體系物理學性質、行為研究生物體系物理學性質、行為Biopolymers: Nucleic acid (DNA, RNA) ProteinMoleculesLipidOtherPROTEINStructuremotifdomainQuaternaryStructurealanineCOOHCH3NH2HPropertyacidzwitterionUnchargedoramino(RPrimaryDistancenonbonding(Y),1chargerdipole r6Transient dipoleinduced dipole rforce LennardJonesmol1， range:～ PaulingPZ0?= 57??= 47?p= z0= Helicesrepetitive secondary structureN
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