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nd arterial stiffness ?The beneficial effect of fluvastatin may result from a statininduced upregulation of endothelial nitric oxide synthase expression and/or activity. Improved Vascular Compliance by AGECrosslink Breaker ? Advanced Glycation EndProduct Crosslink Breaker:ALT711 ? 共入選 93人,隨訪 56天 ? 隨機(jī)接受口服 ALT711 (210 mg, once per day)或安慰劑 ? 入選標(biāo)準(zhǔn): ? 50歲 ? 有動(dòng)脈僵硬度增高的證據(jù): PP 60 mm Hg, SBP140 mm Hg, large artery pliance mL/mm Hg ? 維持原有降壓藥物不變至少 4周 ( ACEI/ARB, β blocker, CCB,利尿劑) ? 排除標(biāo)準(zhǔn):已知的心腦血管疾病、心臟瓣膜病、惡性高血壓、 1型或未控制穩(wěn)定的 2型糖尿病、嚴(yán)重腎臟疾病、活動(dòng)性慢性肺部疾病、房顫、心功能不全等 Improved Vascular Compliance by AGECrosslink Breaker Improved Vascular Compliance by AGECrosslink Breaker day= 28 day= 56 day= 28 day= 56 50 科研 Idea 一定要大量地、仔細(xì)地閱讀文獻(xiàn),千萬不要急于求成; 多聽學(xué)術(shù)報(bào)告、多與同行探討獲得啟示; 總結(jié)你所感興趣的領(lǐng)域內(nèi)尚未探討過但又很有意義的課題; 總結(jié)爭(zhēng)論性很強(qiáng)的問題,反復(fù)比較研究方法和結(jié)論; 細(xì)致地?cái)M定方案; 論證可行性; 善于抓住科研過程中遇到的一些難以解釋的問題,這些問題的解決往往會(huì)成為你的閃光點(diǎn) 。99:24342439. Conclusions ? The role of arterial stiffening was independent of other factors known to affect the oute of uremic patients, namely age, overall duration of ESRD, preexisting cardiovascular disease, degree of LV hypertrophy, BP, and serum albumi