血紅蛋白和肌紅蛋白(文件)
【正文】 port into muscle –O2 faster than other tissues. O2 has low solubility in blood (104 M). Bioinanic Chemistry Myoglobin Binds heme pocket. Polar groups exposed to solvent, Nonpolar groups buried. Bioinanic Chemistry Mb uses heme to bind O2 Feprotoporphyrin IX Heme is planar. Iron atom at center. Coordinated to 4 N’s Bioinanic Chemistry Mb uses heme to bind O2 Fe bound to His (F8) side chain, and O2 or CO2 His E7 Hbonds to O2 to stabilize. (CO binds more tightly than O2). E7 F8 Bioinanic Chemistry Bioinanic Chemistry Hemoglobin 4 subunits ?1, ?1, ?2, ?2. Forms two dimers. Bioinanic Chemistry Hb and Mb have very similar structures Overlay of Mb with Hb ? and ? sununits. Bioinanic Chemistry Blue Blood and Red Blood O2 NH NNNN NH 3 CC H C H 2 C H3C H C H 2C H 2 C H 2 C O O H( C H2 ) 2 C O O HC H 3F eOOOxyhemoglobin lowspin Fe2+ Octahedral The metal is in the plane. Deoxyhemoglobin highspin Fe2+ Square Pyramidal
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鄂ICP備17016276號-1