一般臨床藥物代謝動(dòng)力學(xué)回顧2(1)-wenkub
2023-02-24 17:44:48 本頁(yè)面
【正文】 ory of smoking likely require a higher, lower, or equivalent theophylline total daily dose pared to a nonsmoker? Clinical Question? A patient in the coronary care unit is started on lidocaine for treatment of ventricular arrhythmias. If this patient has severe congestive heart failure (EF 20%), how would the required daily dosage of lidocaine likely be affected? Answer to Clinical Question CLH = QHFpCLi QH + FpCLi CLH = QH CHF Decreases QH HalfLife The time for the concentration of drug in the plasma to decrease by onehalf 10 5 1 * * Time (hours) 1 2 3 Steady State Time Cavg, ss Cmax, ss Cmin, ss Steady State Duration of Drug Administration (HalfLives) Steady State Concentration Reached 1 50 2 75 3 4 5 6 7 Clinical Question? A patient is admitted to the hospital with carbamazepine toxicity. An initial serum concentration is 24 mcg/ml. Assuming a halflife of approximately 18 hours, how long will it take for this patient to reach a serum level of 6 mcg/ml? Answer to Clinical Question 24 mcg/ml 12 mcg/ml 6 mcg/ml 18 hours 18 hours 36 hrs Clinical Question? A patient is started on diltiazem for the treatment of hypertension. (Initial average BP = 160/98) A dosage regimen of diltiazem 60 mg po tid is initiated. Approx. how long will it take for this patient to reach steady state? Answer to Clinical Question Halflife of diltiazem = 6 hours Steady state should be achieved in approximately 5 halflives. Therefore, this patient should reach steady state in approximately 30 hours. Clinica
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