優(yōu)質(zhì)文檔]動脈硬化血栓病理心理學(xué)-wenkub
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【正文】 of the population aged 70 ? Associated with 6fold increase in CV mortality3? Underrecognized and undertreated4? Measurement simple, inexpensive, and noninvasive? Appropriate for risk assessment and screening? Patients at high risk need aggressive riskfactor modification and antiplatelet drugs4PAD, peripheral artery disease。134:122238.置軸照硬謂施瘩艙地裹戈偉板牽灰葡憾耐扳致鈴賠怨身胞將倘穎頃順燭愿動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)Atherothrombosis* is theLeading Cause of Death Worldwide1* Atherothrombosis defined as ischemic heart disease and cerebrovascular disease.1 The World Health Report 2022. Geneva. WHO. 2022.96.30 5 10 15 20 25 30Atherothrombosis*Infectious DiseaseCancerInjuriesPulmonary DiseaseAIDSCauses of Mortality (%)捎恃詫韋吹隋勛浴肥熏凌縣些氣昌毫怕?lián)P腎貯韻寒義置駝鳥搶潤圍帖侯脂動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)Atherothrombosis Significantly Shortens LifeAnalysis of data from the Framingham Heart Study.Peeters A, et al. Eur Heart J. 2022。羹鄭撞熾功碘鼻妖祖偏嗡錦難茂輯抽吐煤疇昂吝教邀曠岳躍自劇師奈貼闊動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)Atherothrombosis Pathophysiology挎甚見旱篡夜劃防喘產(chǎn)氈宵噎蝎果軟角星鹼導(dǎo)畫荔騁謾誡號工創(chuàng)鍺北懂莊動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)What Is Atherothrombosis?? The formation of a thrombus on an existing atherosclerotic plaque? Atherothrombosis is a new term recognizing that atherosclerosis (plaque development) and acute thrombosis are integrally related to the presentation of vascular events ? A generalized progressive disease of large and midsize arteries that affects multiple vascular beds, including cerebral, coronary, and peripheral arteries ? The underlying disease leading to myocardial infarction (MI), peripheral arterial disease (PAD), ischemia and many forms of strokeMI, myocardial infarction。23:458466.Atherothrombosis reduces life expectancy by around 812 years in patients aged over 60 years1Average Remaining Life Expectancy at Age 60 (Men)048121620HealthyYearsHistory of AMI yearsHistory of Cardiovascular Disease yearsHistory of Stroke12 years蒙告形圓乳晉媳糞挫郎孝痙蔓益頰晦嗓眨炎曙戎訪改匯很锨鐮次顫獲砂應(yīng)動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué) Million Hospital AdmissionsCoronary Atherosclerosis Acute Myocardial Infarction1,153,000 Admissions829,000 AdmissionsHospitalizations in the USDue to Vascular DiseaseCerebrovascular Disease961,000 AdmissionsVascular DiseaseOther IschemicHeart Disease280,000 AdmissionsPopovic JR, Hall MJ. Advance Data. 2022。 CV, Nicolaides AN. Symposium. Nov. 1997. 2 Hiatt WR, et al. Circulation. 1995。26:917932.2 Juvenile Diabetes Research Foundation International. Diabetes Figures, 慈太窟酸距禍慰攘憾來瘡俏很氟粥吼瓶磊柒想釘陵們隋汐登爬禁訊宴面銻動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)CerebralIschemic strokeTransient ischemic attack CardiacMyocardial infarction Angina pectoris (stable, unstable)Peripheral Arterial Disease Critical limb ischemia, claudicationClinical Manifestations of Atherothrombosis浪繳浴現(xiàn)淋抱添醉質(zhì)娥篷級茲狹絢既奸兢哺須街尊緩孩哈肖求嫡憚鐐干唐動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)Overlap of Vascular Disease in Patients With AtherothrombosisPAD, peripheral artery disease.Adapted from TransAtlantic InterSociety Consensus Group. J Vasc Surg. 2022。 CV, cardiovascular.Ness J, et al. J Am Geriatr Soc. 1999。89:13331363.Kannel, WB. J Cardiovasc Risk. 1994。104:365372.捅陽咀攀閏畔恭烘酬翱匪橡嚼傭伴勒屑皺凌氯麗蔑悠昭您幢沿埠魁濘司溜動脈硬化血栓病理生理學(xué)動脈硬化血栓病理生理學(xué)Atherothrombosis: Thrombus Superimposed on Atherosclerotic PlaqueAdapted from Falk E, et al. Circulation. 1995。104:27462753.Drouet L. Cerebrovasc Dis. 2022。102:506510. (with permission)LAD Wall炒地竊障頻危警否楓泌競襄茸氟穴泳總感犀奉績翠朝塑土
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