lipidmetabolism脂類代謝-wenkub
2023-05-21 17:52:42 本頁面
【正文】 acyl CoA into mitochondria longer chain acyl CoAs do not readily cross the inner mitochondrial membrane,and require a specific transport mechanism. RCOSCoA CoASH transferase (CH3)3N+ CH2CH CH2COOH OH carnitine (CH3)3N+ CH2CH CH2COOH RCOO acylcarnitine RCOSCoA HSCoA carnitine RCO carnitine RCO carnitine HSCoA carnitine RCOSCoA transferaseⅠ β oxidation transferaseⅡ Inner mitochondrial membrane pathway ? Oxidation(by FAD) ? Hydration ? Oxidation(by NAD+) ? Thiolysis ① oxidation acyl CoA dehydrogenase FAD FADH2 ② hydration RCH2C C CO~CoA H H trans ? 2enoyl CoA enoyl CoA hydratase H2O OH RCH2 CH CH2 CO~SCoA 3hydroxyacyl CoA respiratory chain Ｏ RCH2 CH2CSCoA || OH RCH2 CH CH2 CO~SCoA ③ oxidation NAD+ NADH+H+ dehydrogenase ④ thiolysis CH3CO~SCoA RCH2CO~SCoA （ 1）（ 2）（ 3）（ 4） 3ketoacyl CoA RCH2C ~SCoA O CH2CO CoASH ketothiolase respiratory chain round reaction Oxidation of odd chain fatty acid Racemase B12 CH3CH2CO?CoA Propionyl CoA HOOCCH2CH2CO ?CoA Succinyl CoA yield(C16:0) ? Palmitoyl CoA + 7FAD+7NAD+ + 7CoASH + 7H2O→ 8 acetyl CoA + 7FADH2 + 7(NADH + H+) Palmitoyl CoA + 7 FAD + 7 CoA + 7H2O 7 Reaction cycles of ?Oxidation 8 acetyl CoA + 7 FADH2 + 7(NADH + H+) Summary 2. ?oxidation: 7FADH2 : (14)ATPs produced, 7(NADH + H+): (21) ATPs produced, 3.
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鄂ICP備17016276號(hào)-1