【正文】
1 豬肺炎支原體的免疫時(shí)機(jī)及疫苗的選擇 先靈葆雅動(dòng)物保健市場(chǎng)技術(shù)部 榮 強(qiáng) 2 Mycoplasma hyopneumoniae 豬支原體肺炎 (Mycoplasma pneumonia of swine ?MPS?) Enzootic Pneumonia (EP) 3 M. hyo Disease豬 支原體肺炎 ? First isolated from pig lungs in 1965 ? 1965年首次在豬肺臟中分離 ? One of the most mon and economically important diseases ?最普遍和經(jīng)濟(jì)意義重大的疾病之一 ? A plex interaction between M. hyo and other bacterial and viral infections, and poor management and ventilation. ?主要損失是支原體和其它細(xì)菌病毒的混合感染、飼養(yǎng)管理不善、通風(fēng)不良等綜合因素所致。 4 M. hyo Disease ? One of the primary pathogens causing Porcine Respiratory Disease Complex (PRDC) ?引起 PRDC 的原發(fā)病原之一 ? Affects as many as 99% of . herds ? 99%的美國(guó)豬群都有感染 ? Worldwide significance ?世界范圍內(nèi)養(yǎng)豬生產(chǎn)中流行 5 M. hyo disease ? Economic effects are extremely variable between herds. ?不同豬群的經(jīng)濟(jì)影響差異較大 ? Dependent on cost of inputs, price of pigs, other diseases, etc. ?取決于投入的成本、豬價(jià)、其它疾病的情況等。 ? A MOVING TARGET. 6 M. hyo Disease ? Reduced average daily gain (ADG) ? 降低日增重 ? Reduced feed efficiency (FE) ? 降低飼料報(bào)酬 ? Increased medication costs ? 增加藥物成本 ? Increased cull or lightweight pigs ? 增加淘汰或低體重的豬 ? Etc. 7 8 M. hyo Economic Losses ? M. hyo decreased growth rate % and decreased feed efficiency by % (Pointon, et al,1985) ?肺炎支原體可降低生長(zhǎng)率 %和飼料報(bào)酬% 9 M. hyo disease ? Transmission between pigs: aerosol and direct contact ?豬之間傳播途徑:空氣和直接接觸 ? Transmission between farms: movement of infected pigs ?豬場(chǎng)之間傳播方式:感染豬的移動(dòng) ? Aerosol between farms: Britain ~ km ?豬場(chǎng)之間傳播距離: 10 M. hyo Disease Clinical signs include:臨床 癥狀 ? chronic cough (often dry or nonproductive) ?慢性咳嗽(通常是干咳) ? high morbidity and low mortality ?高發(fā)病率和低死亡率 ? uneven groups of pigs ?豬群內(nèi)生長(zhǎng)不整齊 11 M. hyo disease ? Peak prevalence in Finisher because of: ? 在 育肥期多發(fā)的原因: ? Long incubation period: 潛伏期長(zhǎng) ? Slow spread傳播 緩慢 ? Increased animal density養(yǎng)殖 密度加大 ? Presence of other anisms其他 致病菌的出現(xiàn) 12 M. hyo Pathogenesis ? M. hyo co