細(xì)胞器與疾病ppt課件(已修改)
2025-01-17 16:20 本頁面
【正文】 細(xì)胞器與疾病 （分子醫(yī)學(xué)） A mammalian cell Nucleus ? The nucleus is a membrane bound structure that contains the cell39。s hereditary information and controls the cell39。s growth and reproduction. ? It is monly the most prominent anelle in the cell Nuclear Membranes ? The nuclear content is located in the nuclear lumen and is surrounded by a double membrane or nuclear envelope, posed of inner membrane and outer membrane. ? The outer membrane is contiguous with the ER ? The nuclear membrane contains nuclear pores, which provide selective access into and out of the nuclear lumen ? The inner membrane has a protein lining called the nuclear lamina, which binds to chromatin and other nuclear ponents. The Nuclear Pore Complexes form a continuous aqueous channel between cytoplasm amp。 nucleoplasm nuclear pore plex is large –about 120 million Daltons 30 different proteins found in pore。 basic subunit repeated 16 times. “Central granule now called transporter functions to move molecules through pore. There is a ring of proteins that anchors pore to . and the basket of fibers with unknown function no obvious motor proteins were found The Nucleolus ? The region of the nucleus where portions of chromosomes that contain genes coding for ribosomal RNA are transcribed and ribosomal subunits are assembled ?Stretch of DNA with rRNA genes nucleolar anizing region = (NOR) ? Ribosomal proteins are synthesized in cytoplasm and transported into the nucleus ?These proteins self associate with appropriate rRNA during rRNA synthesis forming immature ribosomal subunits ?Ribosomes finish self assembly in cytoplasm Endoplasmic Reticulum KEDLRGFP 激光共聚焦顯微鏡下的 ER The Endoplasmin Reticulum (ER) is an extensive, extranuclear membrane system with the following functions: ? ER is a home for various enzymes involved in protein folding , drug detoxification, membrane lipid biosynthesis, cholesterol and fatty acid metabolism ? ER is an entry point for protein sorting. Targeting of these proteins is mediated by signal sequence. The membrane proteins are inserted into the ER membrane in their proper orientation. Secreted proteins are translocated into ER lumen and then transported to the destination place Rough and Smooth ER ? Two regions of the ER differ in both structure and function. Rough ER has ribosomes attached to the cytoplasmic side of the membrane. Smooth ER lacks attached ribosomes. Typically, the smooth ER is a tubule work and the rough ER is a series of flattened sacs. The smooth ER has a wide rang
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號-1