【正文】
Antihypertensive and LipidLowering Treatment to Prevent Heart Attack Trial JAMA 2021。288:29812997 ALLHAT : ; :; : . Clinical trial 42,418 patients with hypertension ? SBP 140mmHg and/or DBP 90 mmHg OR ? Took medication for hypertension and had at least one additional risk factor for CHD ? Age 55 years ? NHLBI funded trial Diuretic Chlorthalidone 1225 mg/day (n=15,255) Endpoints: ? Primary – Fatal coronary heart disease and nonfatal MI ? Secondary – Allcause mortality, stroke, and major cardiovascular disease events (CHF, coronary revascularization, angina, and peripheral artery disease) ? Mean followup years ALLHAT JAMA 2021。288:29812997