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2025-07-10 10:15 本頁面
【正文】 osis of both NAFLD and NASH is tissue biopsy. ? NAFLD prises a spectrum of disorders from fatty liver disease to progressive inflammation and cirrhosis. ? Approximately 10% of patients with NAFLD progress NASH, and 8% to 26% of individuals with NASH progress to cirrhosis. ? Retrospective data suggest that, after cirrhosis develops,4% to 27% of cases of NASH transform to HCC. Metabolic syndrome ? It is likely that the majority of those with metabolic syndrome who develop HCC also have cirrhosis before their diagnosis, although this also is unproven. ? Case reports have described patients with NASH who developed cirrhosis and then HCC, and animal models have demonstrated a clear progression from NASH, to cirrhosis, to cancer. Obesity and Cancer Risk Several studies suggest that obese patients also are at increased risk for several types of cancer, both in the United States and in other countries. A large metaanalysis published in The Lancet indicated that increased BMI was associated strongly with the risk of esophageal, thyroid, colon, and renal cell carcinomas in men. In women, endometrial, gallbladder, esophageal, and renal cell carcinomas were increased in those with a 5 kg/m2 increase in BMI. Obesity and Cancer Risk ? Explanations for these increases in cancer incidence have focused on correlations between metabolic syndrome, adipokines, and hormone levels. ? Increasing evidence suggests that obesity may lead to a state of chronic inflammation. Excess consumption of fatty acids and glucose can lead to the in
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