小時(shí)糖耐量試驗(yàn)的臨床意義-文庫吧
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【正文】 in DECODE populations The DECODE group, Diabetes Care 2022。 26: 6169. 051015202530354045I F G amp。 I G TI G TI F G 3039 4049 5059 6069 7079 8089 Prevalence (%) of IGT but not IFG increases with age in DECODE population The DECODE group, Diabetes Care 2022。 26: 6169. Hazards ratio for allcause mortality in subjects without prior history of diabetes Adj. for age, cohorts, sex, chol, BMI, SBP, smoking 2,011,491,77 ? – ? – Fasting plasma glucose (mmol/l) Hazard ratio Adapted from DECODE Study Group, Lancet 1999。354:617–621 1 . 0 00 . 5 80 . 5 20 . 5 60 . 5 90 . 8 20 . 4 70 . 5 00 . 5 40 . 6 60 . 8 40 . 9 20 . 00 . 20 . 40 . 60 . 81 . 01 . 25.255.256.246.257.797.8010.2510.2611.09=11.10Known DM=7.006.106.995.756.094.755.744.75Hazard Ratio (95% CI)2 h o u r g l u c o s e (m m o l / l ) F a s ti n g g l u c o s e (m m o l / l ) Allcause mortality has a linear relationship with 2hour plasma glucose DECODE, Diabetes Care 2022。 26: 688696 010002022300040001 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 1701234513 .02 h o u r pla s ma g luc o s e ( mm o l/ l)CVD mortality by 2hour plasma glucose Frequency Hazard ratio DECODE, Diabetes Care 26: 688696 CVD mortality by fasting plasma glucose 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 170123450202240006000800010000 8 . 5 4 . 0F a s t ing pla s ma glu c o s e ( mm o l/ l)Frequency Hazard ratio DECODE, Diabetes Care 26: 688696 Hazard ratio for mortality by FPG categories, the DECODA Study FPG (mmol/l) (n=5547) (n=462) ? (n=297) P for trend CVD Model 1 Model 2 1 1 () () () () Allcause Model 1 Model 2 1 1 () () () () Model 1: Adjusted for age, sex, cohort, BMI, sysBP, Chol and smoking Model 2: Additional adjustment for 2hPG DECODA Study Group, Diabetologia 2022。 47: 385394 Hazard ratio for mortality by 2hPG categories, the DECODA Study 2hPG (mmol/l) (n=4753) (n=1106) ? (n=447) P for trend CVD Model 1 Model 2 1 1 () () () () Allcause Model 1 Model 2 1 1 () () () () Model 1: Adjusted for age, sex, cohort, BMI, sysBP, Chol and smoking Model 2: Additional adjustment for FPG DECODA Study Group, Diabetologia 2022。 47: 385394 Nondiabetic Diabetic Followup Baseline 2hPG NGT IGT Nondiabetic CHD incidence CVD mortality Allcause mortality Incidence density (no./per 1000 personyears) Qiao et al. Diabetes Care 2022。 26:29102914 Hazard ratio (95% CI) by glucose status at baseline and at follow
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