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【正文】 arrier =胃內(nèi) PH重要 !! pH Matters ? Intragastric pH3: Correlated with DU healing1 ? Intragastric pH4: Correlated with healing of gastric ulcer2 amp。 erosive esophagits3 ? Intragastric pH6: Correlated with clot formation 4,5 amp。 prevention of ulcer rebleeding 1Johnes DB et al. Gut 1987。 28:11207 2Bell NJV et al. Digestion 1992。 51(suppl 1): 5967 3Howden CW et al. Aliment Pharmacol Ther 1990。 4:2533 4Green FJ et al. Gastroenterology 1978。 74:3843 5Patchett SE et al. Gut 1989。 30:17047 Bolus Followed by Bolus Julapalli V et al. Dig Dis Sci 2020。 50:118593 Median pH profiles in eight healthy subjects after receiving an intravenous infusion of 80 mg of pantoprazole followed by 8 mg/hr as a constant infusion Julapalli V et al. Dig Dis Sci 2020。 50:118593 5vials qd 3. Question by PICO ? P (Patient) : 王先生， 45歲男性，從昨天開始解黑便，胃鏡檢查 發(fā)現(xiàn)胃部有一個潰瘍且已有血塊覆蓋 ? I (Intervention) : Pantoprazole ( 40mg/vial) 2 or 5 vials qd Bolus or constant infusion ? C (Comparison) : 1 vial qd, iv bolus ? O (Oute) :潰瘍再出血，開刀或死亡的機會 4. Search strategy1 ? Search Cochrane Database Syst Rev for ulcer bleeding and protonpump inhibitor ? One review article found, but irrelevant 4. Search strategy2 ? Search PubMed for ulcer bleeding and protonpump inhibitor 390 papers found Limits: English,human,met
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