內(nèi)科學(xué)系統(tǒng)性紅斑狼瘡於強-文庫吧
2025-04-24 02:09 本頁面
【正文】 ironmental Factors Sex hormone Helper T cell activity Hyperactivated B cell Immune plex Self antibody + self antigens Multiple system involvement vasculitis 五 . Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing 六 .Clinical menifestations of SLE Multiple system involvement 1. Nonspecific symptom ● fever ● loss of weight ● debilitity and mucosa ● skin symptoms in 80% of patients ● specific features: 40% malar rash discoid rash ● nonspecific features 60% ● photosensitivity 40% ● baldness 40% ● oral ulcer 60% ● Raynaud’s phenomenon 3. Joint and muscle 80% ● arthritisnon erosion ● large and small joints ● myosalgia 40% ● myositis 5% 4. Kidney ▲ renal biopsy can be found renal involvement is all ▲ present in about 70% of patients ▲ 25% patients are dead in cause of renal involvement 5.
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