脂質(zhì)體運(yùn)用于胰島素口服給藥治療糖尿病的可能性外文翻譯-文庫(kù)吧
2025-04-16 18:45 本頁(yè)面
【正文】 yer slow controlled release, can play a steady drop in blood sugar. In recent years, insulin liposomes due to its broad prospects attracted more and more attention. In insulindependent diabetes mellitus, treatment with subcutaneous injections of insulin in adequate doses not only does not prevent the development of diabetic plications in many cases, in particular, liver pathology, but also promotes the appearance of lipodystrophies. Insulin injected in this way enters the general circulation earlier than the liver. On the contrary, under physiological conditions it immediately enters the liver through the portal vein from the pancreas, and 5060% of the newly secreted insulin is retained there . In view of this, the need for seeking a new means of introduction of the hormone lacking in the organism, closer to the physiological pathway, is understandable ..It would be most convenient to introduce insulin per os, if it were protected from the action of the proteolytic enzymes of the gastrointestinal tract. Repeated attempts have been made to introduce insulin into the organism without , for example, it has been suggested that a mixture of insulin with a vasodilating preparation be adsorbed under the tongue。 however, the necessity of using large doses of the preparation over a prolonged period of time prevents the introduction of this method into clinical sugarlowering effect of insulin administered to animals intraduodenally in a wateroil emulsion has also been suggested .Effectiveness of rectal introduction of insulin in the form of an emulsion or suppositories has been reported in a number of studies~ A decrease in the blood sugar level has been detected after oral administration of insulin with synthetic polymers. A lowering of hyperglycemia has been detected in diabetes mellitus patients after inhalation of a stable suspension of insulin in a propellant [7]. In recent years attempts have been undertaken to introduce insulin per os in liposomes, prepared from phospholipids subjected to ultrasonic has been shown that insulin enclosed within liposomes is protected from the action of proteolytic enzymes of the stomach and is absorbed by the mucous membrane of thegastrointestinal tract, followed by delivery to the liver. The purpose of the present work was to investigate the effectiveness of insulin introduced per os in liposomes on the course of diabetes mellitis. The liposomes were produced by the Bangham method [ii] from a mixture of phosphatidylcholine and cholesterol in an 8:2 mole ratio on the basis of I0 mg lipids per ml of suspension,followed by ultrasonic treatment. The method was described in detail in .Simple bovine insulin was used in a dose of about two units per rat, calculated so that about 5% insulin was incorporated into the liposomes..In the experiment we used 128 noninbred white mellitus developed in the animals after
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