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ontaining tyrosinase(酪氨酸) . Function: produce melanin granules which prevent ultraviolet radiation from damaging skin. (2) Langerhans cells(朗格漢斯細(xì)胞) : Location: among spinous cells ? LM: starshaped, lobed nucleus. ? Function: Identify, bind and process and present foreign antigens to lymphocytes. (3) Merkel cells(梅克爾細(xì)胞) : Location: among basal cells. Structure: dense granules, chemical synapse formed between the cell base and nerve ending. Function: perception of stimulation /mechanoreceptor. Merkel cell Nerve ending Basal cell Structure related with dermal protection 1. Stratum corneum: cells are dried dead, cytoplasm are full of wearresisting keratin. 2. Intercellular space is full of lipid substance (lamellar granule contents). 3. Melanocytes produce melanin granules which prevent ultraviolet radiation from damaging skin. 4. Langerhans cells play the role in immune defence. II. Dermis 1. Papillary layer: Loose CT, capillaries, nerve endings. 2. Reticular layer: Dense CT Sweat glands Sebaceous glands Hair follicles Hypodermis III. hair shaft hair root Arrector pili muscle hair follicle hair bulb hair papilla epithelial root sheath connective tissue sheath Skin appendages IV. 1. Hair LGR5 and LGR6 indicate different stemcell populations along hair folli