哈醫(yī)大第一臨床醫(yī)學院心內(nèi)科(已改無錯字)
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【正文】 可能與其 抗氧化作用 有關(guān)。 Hypertension, 2020, 51: 22522231 The First Clinical College of Harbin Medical University ? 美國全國高血壓教育項目協(xié)調(diào)委員會（ NHBPEP） 推薦的 鉀與鈉攝入比為 2： 1。 ? 陜西農(nóng)民調(diào)查，攝取鉀約為 35 mmol/ d ， 而鈉攝入為 230 mmol/ d , 鉀與鈉攝入比 僅 : 1。 ? 補鉀最可通過多食用含鉀豐富的 水果 、 蔬菜 等或 添加鉀鹽 (低鈉鹽）。 The First Clinical College of Harbin Medical University ? 保證良好睡眠。 ? 睡眠障礙者 非杓型高血壓發(fā)生率增加 3倍 。 Blood Press. 2020。16(2):1015 The First Clinical College of Harbin Medical University ? 對嚴重自主神經(jīng)病變導(dǎo)致 仰臥位高血壓者 , 睡眠時頭部抬高 有助于降低仰臥位血壓 。 The First Clinical College of Harbin Medical University 藥物治療 ?Blockers of the RAAS ? 腎素活性夜間增加，到凌晨達高峰。 ? OSAHS 患者 RAAS亢進， RAAS拮抗劑 能夠明顯 降低 24 h 血壓，且具改善呼吸暫停及睡眠結(jié)構(gòu)作用。 ? Evening dosing results in better nocturnal BP reduction and increased dipping than with morning dosing. Pharmaco. Ther. 111(3), 629–651 (2020). J. Hypertens. 23(10), 1913–1922 (2020). Hypertension 50(4), 715–722 (2020). Chronobiol. Int. 26(1), 61–79 (2020). The First Clinical College of Harbin Medical University ?CCB ? 180 patients (50% nondippers) receiving nifedipine GITS in a prospective, openlabel, parallelgroup design paring morning and bedtime administration. Bedtime dosing resulted in better 24h SBP control (9% vs % fall。 p = ) , also acpanied by greater sleepBP lowering (% vs 6% fall。 p = ) and a decrease in the number of nondippers from 51% to 35%. Am J Hypertens 2020, 21(8):94854 The First Clinical College of Harbin Medical University ?β受體阻滯劑 ? The BPlowering effects are more pronounced during wakefulness(失眠 ) and OSAHS. ? 非選擇性 β受體阻滯劑（ 普奈洛爾 ） 增加氣道阻力和呼吸暫停次數(shù)，應(yīng)避免使用。 ? βblockers have not been well studied to date. . Hypertens. 14(5), 453–459 (2020). Pharmaco. Ther. 111(3), 629–651 (2020). The First Clinical College of Harbin Medical University ?利尿劑 利尿劑對血壓晝夜模式 無明顯影響 （鹽敏感高血壓除外） , 仍有待大規(guī)模臨床研究證實。 Circulation 100(15), 1635–1638 (1999) Chronobiol. Int. 25(6), 950–970 (2020) Hypertension 47(3), 352–358 (2020). The First Clinical College of Harbin Medical University The ABPM substudy of the AngloScandinavian cardiac outes trial (n=1905) showed a more significant reduction of nocturnal BP with an amlodipine–perindopril regimen than with atenolol–thiazide, despite the fact that the daytime BP was higher in the former group, which might account for the lower cardiovascular events in the amlodipine–perindopril group. J Hypertens 2020。 27: 876–885 The First Clinical College of Harbin Medical University 其他藥物 ?褪黑素 ? 由松果體腺分泌，能夠改善內(nèi)皮功能，增加 NO合成， 導(dǎo)致血管擴張和降壓效應(yīng)。 ?對夜間高血壓治療作用仍 有待大規(guī)模臨床研究證實 。 Am. J. Med. 119(10), 898–902 (2020). Am. J. Hypertens. 18(12 Pt 1), 1614–1618 (2020) The First Clinical College of Harbin Medical University ?阿司匹林 ? A potent antioxidative agent that reduces vascular production of superoxide, prevents angiotensin II–induced hypertension, and induces NO release. The First Clinical College of Harbin Medical University ? 257 patients with mild hypertension (100 mg) . ? Signi
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