【正文】 r the new classification system,第二十七頁，共四十頁。 thus, it is important to be familiar with the characteristics of GGNs with malignant potential, as timely surgical resection will improve patient survival and quality of life, and for patients with benign GGNs, unnecessary surgical procedures can be avoided.,第二十八頁，共四十頁。,This demands further investigation of this particular abnormal imaging finding to minimise misdiagnosis. In the management of GGNs in our patients, clinical guidelines from the Fleischner Society and National Comprehensive Cancer Network (NCCN) were referenced . Each individual case was discussed by a multidisciplinary team, including diagnostic radiologists, thoracic surgeons and pathologists, to generate consequent management strategies. All patients received adequate followup observation with/without supportive or antiinflammatory treatment, which explained the fact that four GGNs disappeared prior to the next scheduled CT examination.,第三十頁，共四十頁。,Tumour biology studies have revealed that vasculature remodelling or neoangiogenesis is one of the initiating events occurring in the early stage of tumour development. Therefore, analysis of GGNs and related blood supplying vessels could provide information on GGN differentiation. Small blood vessels and the relationships between vessels and lesions can be readily revealed and evaluated in CT images acquired with modern multidetector scanners, especially when imaging data are postprocessed using advanced computer techniques, including MPR and CPR. Many studies have demonstrated that relationships between SPNs and vessels, especially the vascular convergence sign (VCS), are valuable for estimation of the malignancy potential of SPNs,第三十二頁，共四十頁。,As a result , involved vessels might appear distorted, rigid or concentrated towards the lesion. Thus, it is reasonable to postulate假設(jiǎsh232。,Type III vascular morphological changes were observed more often in the IAC than MIA subgroup, indicating that with increasing malignancy, fibre hyperplasia stimulated by malignant tissues may become more severe, and subsequently impacts on vasculature become aggravated. Further more， tumour metabolism is faster than in normal tissues。,Some studies have shown that endogenous and/or extrinsic tumor angiogenesis and neovascularisation could be the driving factors of vascular abnormalities observed in malignant early stage. As a CT imaging sign, VCS describes a relationship between SPNs and vessels, one or multiple vessels concentrating towards and passing through lesions or being truncated at the edge of lesions.,第三十六頁，共四十頁。,A major drawback of this study is the limited number of cases, especially in the benign group, which may compromise the diagnostic power. Hence, a prospective clinical trial with more GGN cases is warranted to further evaluate and validate the diagnostic value of findings in this study. Additionally, this study could be strengthened if the analysis were conducted with a combination of vessel types and other GGN features, such as size and mass. Mass measurements can reflect lesion growth earlier with less variability than diameter measurements .,第三十八頁，共四十頁。,內(nèi)容(n232。ng)總結,Multidetector spiral CT study of the relationships between pulmonary groundglass nodules and blood vessels。,