老年和青壯年患者腰叢-坐骨神經(jīng)阻滯時(shí)局麻藥藥doc-閱讀頁
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【正文】 esth Pain Med 2006,31(5):417421.[6] 肖潔,王祥瑞,蔡美華,等. 鹽酸羅比卡因腰叢坐骨神經(jīng)阻滯的藥代動(dòng)力學(xué)研究. 臨床麻醉學(xué)雜志 2005,21(11):731733.[7] 林惠華,張威,孫曉雄. 利多卡因用于坐骨神經(jīng)“三合一” 2005,27(1):3538.[8] 郭獻(xiàn)陽,徐旭仲,陳麗梅,等. 羅哌卡因單用及復(fù)合不同濃度利多卡因?qū)ψ巧窠?jīng)起效時(shí)間的影響. 溫州醫(yī)學(xué)院學(xué)報(bào) 2007,37(3):240243.[9] 董錫臣,黃宇光. 性別對羅哌卡因阻滯犬坐骨神經(jīng)時(shí)藥代動(dòng)力學(xué)的影響. 中華麻醉學(xué)雜志 2007,27(8):732734.[10] Birt DJ, Cummings GC. The efficacy and safety of % levobupivacaine vs % bupivacaine for peribulbar anaesthesia. Eye 2003,17(2):200–206.[11] atajczak,Enselme M, Estebe JP, et al. Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep. Br J Anaesth 2007,99(6):881890.[12] 王廣基,藥物代謝動(dòng)力學(xué),化學(xué)工業(yè)出版社,2005,97104.[13] McCartney CJ, Murphy DB, Iagounova A, et al. Intravenous ropivacaine bolus is a reliable marker of intravascular injection in premedicated healthy volunteers. Can J Anaesth 2003,50(8):795800.[14] Paut O, Schreiber E, Lacroix F, et al. High plasma ropivacaine concentrations after fascia iliaca partment block in children. Br J Anaesth 2004,92(3): 416418.[15] Knudsen K, Beckman Suurkula M, Blomberg S, et al. Central nervous and cardiovascular effects of . infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997,78(5):507514.[16] Simon MJ, Veering BT, Vletter AA, et al. The effect of age on the systemic absorption and systemic disposition of ropivacaine after epidural administration. Anesth Analg, 2006,102(1):276282.[17] 劉娜,高雪慶,于萬秋,等. 腰叢 坐骨神經(jīng)阻滯用于老年病人膝關(guān)節(jié)鏡手術(shù)的臨床觀察. 大連醫(yī)科大學(xué)學(xué)報(bào) 2007,29(3):291292.論文圖表表1 兩組一般資料比較(n=10，s)組別年齡(y)體重(kg)身高(cm)性別(男/女)A組72757816257/3B組381062616657/3表2 兩組患者利多卡因和羅哌卡因的平均藥代動(dòng)力學(xué)參數(shù)(s)藥代動(dòng)力學(xué)參數(shù)利多卡因羅哌卡因A組B組A組B組Cmax (mg/L)**Tmax (min)196221421162212t1/2z(min)1817015151478455*264154AUC(0t)(mgmin1)2438525980545253588228AUC(0∞)(mgmin1)3211193171231323985993638CLz/F (Lkg1)與B組相比，*P﹤.圖1 兩組利多卡因平均血漿藥物濃度時(shí)間曲線圖2 兩組羅哌卡因平均血漿藥物濃度時(shí)間曲線15 / 15
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