氰轉化為酰胺-在線瀏覽
2024-09-15 08:19本頁面
【正文】 的水解轉化為酰胺，并在條件較為劇烈時，很容易進一步水解成酸。目前有許多方法報道，有時需要根據底物的特性選擇酸性，堿性或中性的水解條件。經典合成反應標準操作— Mitsunobu 反應 經典化學合成反應標準操作目 錄1． 前言…………………………………………………………………22． 氰基轉化為酯…………………………………………………………23． 氰基轉化為酰胺…………………………………………………2…………………………………………………………2…………………………………………………………3 6. 從氰基合成酰胺腈加水可以分解為伯酰胺。由于伯酰胺會繼續(xù)水解為羧酸，一般要控制水解的條件。作為中性的條件，也有文獻報道使用鎳或鈀催化劑的方法。但乙烯基或芳基腈的水解條件則要求劇烈得多，一般需要強酸條件，而且一般不會進一步水解。利用NaOH(aq.)CH2Cl2相轉移催化體系，DMSOK2CO3體系[2]可以用于各種腈水解為伯酰胺。 the mixture is stirred vigorously. Within a period of 20–40 minutes the benzyl cyanide goes into solution. During this time, the temperature of the reaction mixture rises about 10176。, and the thermometer is replaced by a dropping funnel from which 800 ml. of cold distilled water is added with stirring. After the addition of about 100–150 ml., crystals begin to separate. When the total amount of water has been added, the mixture is cooled externally with ice water for about 30 minutes. The cooled mixture is filtered by suction. Crude phenylacetamide remains on the filter and is washed w
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