diseaseofhematopoieticandlymphoidsystem-在線瀏覽
2024-09-01 09:40本頁面
【正文】 t(4:11) 行為：高惡，幾個月內(nèi)死亡。 免疫表型： CD19， CD20， CD23（ +） 遺傳特點： IgH和 IgL基因重組 30% 12三體性 行為： 低惡 （ 3） Follicular lymphoma 濾泡型淋巴瘤 腫瘤性濾泡特點： ① 濾泡遍及整個淋巴結(jié) ② 瘤細胞相對一致性 ③ 無著色體巨噬細胞或偶見 ④ 無淋巴帽 ， 分界不清 ⑤ 濾泡間網(wǎng)纖維受壓 免疫表型 CD19， CD20， CD10（ +） ， bcl2（ +） 遺傳特點 t(14:18) 行為 低惡 (4) Diffuse large Bcell lymphoma 彌漫性大 B細胞淋巴瘤 形態(tài)特點： ① 瘤細胞體積大 ， 類似中心母細胞 、 免疫母細胞 ② 核圓形或卵圓 ， 染色質(zhì)邊集 ③ 核仁多個或單個 ， 顯著 免疫表型 CD19， CD20（ +） 遺傳特點 30% t(14:18) bcl2蛋白 行為 高惡，但 50%可治愈。 有的大小不等呈多形性 。 (7) Burkitt lymphoma 伯基特淋巴瘤 非洲淋巴瘤 Burkitt’s lymphoma Brukitt’s lymphoma was described initially in Africa, where it is endemic in some parts, but it is also ocure sporadically in nonendemic area. Only very rare cases have been recorded in European and North America. This disorder is relationship of the EpsteinBarr viruses. Both the African and non Africa cases are found largely in children or young adults. The disease rarely arises in lymph nodes, but usually appears in the jaw or ovaries (retroperitoneal tissues in males) this disease grows extremely rapidly and spreads extensively, leading quickly to plication. Histological appearance is typical and striking 1. diffuse proliferation of lymphoblasts (B cell type) cell medium sized and uniform, mitoses frequent. 2. Scattering of macrophages containing debris desired from very rapid cell turnover contributing ‘starry sky’. These benign macrophage are diffusely distributed among the tumor cell. The macrophage often sounded by a clear space. Leukemic transformation may occur, but is unmon, these tumors respond well to aggressive chemotherapy and long remissions have been reported. However, in most cases a relapse occurs, and a majority of patients die with in 5 years. Burkitt lymphoma (8)Mycosis fungoides Mycosis fungoides are unmon lymphoid malignancies that are primary in the skin. It is infrequent T cell lymphomas. These disease usually affects males 4060 years of age. Grossly: The lesions begin as poorly defined areas of eczema, followed by formation of plaques and ultimately of multiple nodules. The nodules often rapture and bee ulcer. Histologically: This disease is characterized by dermal infiltrates of atypical lymphoid cell that invade the epidermis. The neoplastic cell (mycosis cells) have deeply lobulated or cerebraform nuclei. Immunology studies indicate the presence of T cell markers on mycosis cells. 多發(fā)性骨髓瘤和漿細胞相關(guān)腫瘤 1. 中老年人常見 2BCell 源性 .單克隆性 r 病 Section 4 Leukemia A. Definition Leukemia is malignant tumor of the hemotopoietic stem cell. In most cases, the leukemic cell infiltrate the blood, Liver, Spleen, Lymph node and other tissues. B. Classification 1. According the clinic course Acute Chr
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