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【正文】 dult Spetzler amp。 Pathophysiology ?absence of normal capillary system ?usual function displaced ?asymptomatic at birth ?vessels change with time ?may develop aneurysms ?parenchymal changes within and around the lesion ?site frequency is proportional to brain volume Pathology amp。 Pathophysiology ?absence of normal capillary system ?usual function displaced ?asymptomatic at birth Pathology amp。 Pathophysiology ?absence of normal capillary system Pathology amp。 transcerebral circ39。CEREBRAL ARTERIOVENOUS MALFORMATIONS AVM: a TLA for the CNS Incidence ?% at autopsy ?Slight male preponderance ( to ) ?Congenital lesions (although rarely familial) Embryology ? First half of third week of gestation ?epiblastic cells migrate to form mesoderm ?mesodermal cells differentiate to arterial and venous vessels on the surface of the embryonic nervous system Embryology ? First half of third week of gestation ?epiblastic cells migrate to form mesoderm ?mesodermal cells differentaite to arterial and venous vessels on the surface of the embryonic nervous system ? Seventh gestational week ?vessels sprout branches amp。 perate developing brain ?reach the graywhite interface, either loop back to pial surface or traverse entire neural tube, thus epicerebral amp。n ?eventually connect arterial and venous systems by around the twelfth week Pathology amp。 Pathophysiology ?absence of normal capillary system ?usual function displaced
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