疫4月17hypersensitivity-展示頁
2024-08-26 14:34本頁面
【正文】 mediate 速發(fā)型 ? Type II Cytolytic 細(xì)胞溶解型 ? Type III I C 免疫復(fù)合物型 ? Type IV Delayed 遲發(fā)型 Type I Hypersensitivity (Immediate速發(fā)型 ， Anaphylaxis過敏反應(yīng) ) I Features 1. quick 2. various, serious 3. IgE mediated 4. no plement involved 5. Obvious individual variation amp。 basophil: blood. 2) IgEFceR 3) activation of mast cell Biological activities of mast cell and basophil basophil mast cell 5 min after activation 60 min after activation mediators (1)Histamine 組胺 (2)Kinnogenase 激肽原酶 synthesized mediators (1)LTs 白三烯 (SRSA) (2)PGD2 前列腺素 (3)PAF 血小板活化因子 (iv) Biological Mediators III Common Diseases in Clinical 1 Anaphylactic shock過敏性休克 1) Medicine (., penicillin) Penicillin (372, hapten) In tissue, blood (~) → 6~24h penicilloyl, penicillenic acid (青霉噻唑醛酸 、 青霉烯酸 )+protein → IgE 2) Xenogenic serum異種動物血清 2 Allergy of respiratory tract Asthma 1) Bronchia asthma 支氣管哮喘 2)Allergic rhinitis 過敏性鼻炎 Rhinitis 3 Allergy of digestive tract 胃腸道過敏反應(yīng) Hives蕁麻疹 4 Allergy of skin 皮膚過敏反應(yīng) Reactions of immediate hypersensitivity The wheal can involve an area of skin as large as several centimeters in diameter. The wheal and flare response typically subsides after about 15 to 20 minutes. IV Diagnosis test detection test Skin tests with Grass pollen allergen植物花粉 in a patient with typical summer hay fever枯草熱 Read at 20 min Skin tests with different allergens detection V Preventionamp。 2 Type Ⅱ Hypersensitivity (Cytotoxic type 細(xì)胞毒性 Cytolytic type 細(xì)胞溶解型 ) Feature: ?① Ab: IgG、 IgM ?② Complement involved ?③ Cell: Mφ、 NK ?④ Reaction on cell ? 一、機(jī)制 細(xì)胞表面抗原 刺激機(jī)體 產(chǎn)生 IgG／ IgM 抗體結(jié)合細(xì)胞表面抗原 調(diào)理吞噬 激活補(bǔ)體 NK細(xì)胞 吞噬細(xì)胞 刺激或阻斷作用 ADCC 吞噬靶細(xì)胞 溶解靶細(xì)胞 靶細(xì)胞功能亢進(jìn)或降低 細(xì)胞溶解 /炎癥反應(yīng) 二、 Common Diseases in Clinical: ? (一 ) Blood transfusion reaction 輸血反應(yīng) ABO blood groups and serum antibodies blood group (phenotype) genotype antigen serum antibody A AA, AO A AntiB B BB, BO B AntiA AB AB A and B None O OO H AntiA AntiB ? (二 ) Hemolytic disease of the newborn 新生兒溶血癥 (erythroblastosis fetalis)
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號-1