diseaseofhematopoieticandlymphoidsystem-展示頁
2024-08-06 09:40本頁面
【正文】 on Section two Leukopenia 白細胞 減少癥 Morphology: hypercellularity marked decrease in maturing granulocytic precursors in the marrow Clinical course Malaise chills and fever followed by marked weakness and fatigability Section two Reactive leukocytosis 反應(yīng)性白細胞增多癥 mononucleosis lymphadenitis acute nonspecific lymphadenitis chronic nonspecific lymphadenitis disease Section 2 Lymphooid neoplasms Malignant Lymphomas Summary Concept: Lymphomas are malignant tumor which origin from lymph node and other lymphoid tissue. Classification: Two main groups: 1 Hodgkin’s disease(1020%) 2 non Hodgkin’s lymphoma (8090%). Malignant Lymphoma Lymphocytic leukemia Certain important principles must be emphasized % is B Cell origin with Tcell tumors making up most of the remainder tumor of mature B cell arise from and recapitulatethe follicular growth pattern of normal B cells tumors of the immune system, Lymphoid often disrupt normal immune regulatory mechanisms 4. All lymphoid neoplasms are derived from a single transformed cell and are therefore monoclonal. NHLs often present as involvement of a particular tissue site, sensitive molecular assays usuall show that the tumors is widely disseminated at the time of diagnosis. Hodgkin’s Lymphoma(HL) Hodgkin’s Disease (HD) Hodgkin’s disease is disorder involving primarily the lymphoid tissue, the disease, which in the monest type of lymphoma, may occur at any age but there are 2 peaks of incidence ① around adolescence. ② in late middle and older age. Morphology Site: the disease begins in a single lymph node (e. s. cervical) followed by spread to adjacent nodes and to other ans in a fairly consistent pattern. Grossly: single to multiples mass, graywhitecolor,soft,uniform fishflesh . yellowwhite necrosis on the cut surface. Microscopy: 1. The normal architecture of lymph node has been destroyed and replaced by tumour tissue, the variety cells present in the tumour tissue. one constant feature is the presence of Reed Stern berg (RS) cells. ① Typical RS cell large cell: 3060μm dram. Amphophilic cytoplasm large nuclei: two or more nuclei。 when the RS cell contain two large nuclei. We term it mirror image nuclei。 彌漫性 彌漫型 中心細胞性（套細胞） 單核細胞樣，包括邊緣帶細胞 高度惡性 中心母細胞性 免疫母細胞性 Burkitt淋巴瘤 大細胞間變性（ Ki1+） 淋巴母細胞性 罕見類型 淋巴細胞性 慢性淋巴細胞白血病 前淋巴細胞白血病 小細胞，腦形 蕈樣霉菌病， Sezary綜合征 淋巴上皮樣 血管免疫母細胞性 T區(qū)淋巴瘤 多形性，小細胞性（ HTLV1 177。 ） 免疫母細胞性（ HTLV1 177。 ② 非曲核型 免疫表型： TdT(+) SIg() CD10， CD19（ +） 前體 B CD2， CD3， CD7（ +） 前體 T 遺傳特點：多倍體 50個染色體 t(12:21), t(9:22)
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