【正文】
ronic lead reliability issues: ? Crush, fracture, abrasion, etc. (in: pocket, subclavian V., the heart) ? System connections (battery change +++) ? Device pocket plications: ? Erosion through the skin: % after 1st implant, % after replacement ? Pain at incision/pocket 1. Unmet Needs in Cardiac Pacing ? Infection ? Up to % within a year after procedure ? Up to 5% of the entire population with endocarditis ? 1% risk of death and 2% risk of major plications at lead extraction ? Lead interactions with vasculature and heart structures: ? Tricuspid valve impairment (20% of implanted pts with TV regurgitation) ? Venous stenosis/thrombosis (up to 25%) ? SVC syndrome (1%) ? Cosmesis ? Availability of specialists for implant/followup Emerging Markets 1. Unmet Needs in Cardiac Pacing ? Pacing lead failure ? Up to 21% within 10 years after pacemaker implantat