多腫瘤標(biāo)志物蛋白芯片檢測(cè)系統(tǒng)在臨床應(yīng)用中的評(píng)價(jià)doc-展示頁(yè)
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【正文】 tification of clinical applications to cancer diagnosis with multitumor markers protein chip and its speeificity and sensitivity in detection of noncaneer subjeets and healthy controls. Methods:The serum levels of 12 tumor markers，includingCA199，NSE，CEA，CA242，CA125，CA153，AFP，F(xiàn)erritin，F(xiàn)ree一PSA，PSA，βHCG and HGH [通訊作者] 鄒雄(1955 ) ,男, 教授,博士研究生導(dǎo)師,研究方向:腫瘤免疫。運(yùn)用蛋白芯片技術(shù)聯(lián)合檢測(cè)多種腫瘤標(biāo)志物可以明顯提高惡性腫瘤診斷的敏感性，可應(yīng)用于預(yù)后及療效觀察，同時(shí)也可以作為無(wú)癥狀人群的早期腫瘤普查手段之一，對(duì)腫瘤高危人群的普查具有一定的指導(dǎo)意義。C12對(duì)健康人群檢測(cè)的特異性為95%，%。同時(shí)對(duì)惡性腫瘤組的153例陰性標(biāo)本用E170全自動(dòng)免疫分析儀進(jìn)行比對(duì)分析。多腫瘤標(biāo)志物蛋白芯片檢測(cè)系統(tǒng)在臨床應(yīng)用中的評(píng)價(jià)李心河1，單寧寧1，2,高揚(yáng)1，王惠敏1，劉延紅1，夏洪印1，鄒雄1，侯明21. 山東大學(xué)齊魯醫(yī)院檢驗(yàn)科中心實(shí)驗(yàn)室，濟(jì)南，2500122. 山東大學(xué)齊魯醫(yī)院血液科，濟(jì)南，250012[摘要]目的:評(píng)價(jià)多腫瘤標(biāo)志物蛋白芯片在健康人群的普查、腫瘤的早期診斷及監(jiān)測(cè)預(yù)后的應(yīng)用。方法:使用HD2OO1A多腫瘤標(biāo)志物蛋白芯片檢測(cè)系統(tǒng)（C12）測(cè)定分析8330例惡性腫瘤患者，9657例良性疾病患者和23531例健康體檢者血清12種常見(jiàn)腫瘤標(biāo)志物(CA199，NSE，CEA，CA242，CA125，CA153，AFP，F(xiàn)ER，fPSA，PSA，βHCG及HGH)的水平。結(jié)果:惡性腫瘤組的陽(yáng)性率(%)顯著高于良性疾病組(%)和健康體檢組(%)(P)。結(jié)論:多腫瘤標(biāo)志物蛋白芯片檢測(cè)技術(shù)具有較高靈敏度和特異性。關(guān)鍵詞:腫瘤標(biāo)志物。 電話：053182169186 zx2186benign disease and 23531 healthy :The Positve rates were measured with the detective system in 8330 malignant tumor Patients，9657 Patients with were(%)in malignant tumor，(%)benign disease and(%)healthy groups， malignant tumor group had signifieantly higher positive rate than that of the :Combined measurement of multiple serum tumor markers using protein biochip technique can significantly increase the diagnostic sensitivity for malignant tumor，and can also be used as an earlier tumorscreening tool to asymptomatic people，especially to the high risk ones.
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