【正文】
(q13。q21) () Frequency 95% 1~2% rare rare rare Fusion gene PMLRARa PLZFRARa NuMARARa NPMRARa STAT5bRARa 100% 100% yes yes yes RARaPML RARaPLZF RARaNuMA RARaNPM RARaSTAT5b 60~70% 100% no yes no Nuclear in 100 micro speckles localized in microspeckle sheet like microspeckle localization which maybe microspeckles pattern aggregation pattern, maybe localized in be localized cytoplasm in cytoplasm Response to ATRA good no, may respond good yes no to ATRA+GCSF Chemo good no, may respond to chemo/ATRA Arsenic good, with no PLZFRARa not known not known not known degradation of degradation PMLRARa PML RAR ? L