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【正文】 from adult neural stem cells by reprogramming with two factors[J]. Nature, 2008, 454(7204):  646650.[11] Dimos JT, Rodolfa KT, Niakan KK, et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons[J]. Science, 2008, 321(5893):  12181221.[12] Park IH, Arora N, Huo H, et al. Diseasespecific induced pluripotent stem cells[J]. Cell, 2008, 134(5):  877886.[13] Mali P, Ye Z, Hommond HH, et al. Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts[J]. Stem Cells, 2008, 26(8):  19982005.[14] Huangfu D, Maehr R, Guo W, et al. Induction of pluripotent stem cells by defined factors is greatly improved by smallmolecule pounds[J]. Nat Biotechnol, 2008, 26(7):  795797.[15] Aasen T, Raya A, Barrero MJ, et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes[J]. Nat Biotechnol, 2008, 26(11): 12761284.[16] Maherali N, Ahfeldt T, Rigamonti A, et al. A highefficiency system for the generation and study of human induced pluripotent stem cells[J]. Cell Stem Cell, 2008, 3(3):  340345.[17] Huangfu D, Osafune K, Maehr R, et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2[J]. Nat Biotechnol, 2008, 26(11): 12691275.[18] Stadtfeld M, Nagaya M, Utikal J, et al. Induced pluripotent stem cells generated without viral integration[J]. Science, 2008, 322(5903): 945949.[19] Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse ind
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