histocompatibilitycomplex(主要組織相容性復(fù)合體)-文庫吧資料
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【正文】 tions of MHC and HLA. ? The position of HLA gene plex ? The structure, distribution and functions of MHC class Ⅰ and Ⅱ molecules. ? 靜夜四無鄰，荒居舊業(yè)貧。 HLA與疾病的關(guān)系 （一） (relative risk，相對危險率 ) 。CHAPTER 11 THE MAJOR HISTOCOMPATIBILITY COMPLEX I. Introduction ? Major histopatibility antigen system ? Major histopatibility plex: – A large geic locus that includes the highly polymorphic genes encoding the peptidebinding molecules recognized by T lymphocytes. The MHC locus also includes genes encoding cytokines, molecules involved in antigen processing, and plement proteins. ? H2 plex: murine MHCs ? HLA: human MHC which is known as the human leucocytes antigen system. – Three classes of MHC genes closely linked on chromosome ? ClassⅠ gene ? ClassⅡ gene ? ClassⅢ gene II. The anization of murine and human MHC 1. Mouse H2 plex: – ClassⅠ gene: K, DL class Ⅰ molecules (αchain） – ClassⅡ gene: I class Ⅱ molecules (αβchain) – ClassⅢ gene: S plement, TNF S K I D/L Chr. 17 centromere H2 2. Human HLA plex: DP DN DO DQ DR B C
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