第五章固體制劑-2膠囊劑、滴丸和膜劑-文庫吧資料
2025-07-27 17:13本頁面
【正文】 upplied as closed units to the pharmaceutical manufacturer. Before use, the two halves are separated, the capsule is filled with powder (either by placing a pressed slug of powder into one half of the capsule, or by filling one half of the capsule with loose powder) and the other half of the capsule is pressed on. James Murdock patented the twopart telescoping gelatin capsule in London in 1847. ?In 1834, Mothes and Dublanc were granted a patent for a method to produce a singlepiece gelatin capsule that was sealed with a drop of gelatin solution. They used individual iron moulds for their process, filling the capsules individually with a medicine dropper. ?All modern softgel encapsulation uses variations of a process developed by . Scherer in 1933. His innovation was to use a rotary die to produce the capsules, with the filling taking place by blow molding. This method reduced wastage, and was the first process to yield capsules with highly repeatable dosage. （ 1）能掩蓋藥物不良嗅味、提高藥物穩(wěn)定性； （ 2）藥物在體內(nèi)起效快； （ 3）液體藥物的固體劑型化； （ 4）可延緩藥物釋放和定位釋藥 . 膠囊劑的特點(diǎn)： （二）膠囊劑的分類 膠囊劑 硬膠囊劑 軟膠囊劑 (亦稱膠丸劑 ) (hard capsules) (soft capsules） 緩釋膠囊劑 控釋膠囊劑 腸溶膠囊劑 (1)硬膠囊劑： 將一定量藥物及適當(dāng)?shù)妮o料（也可不加輔料）制成均勻的粉末或顆粒，填裝于空心硬膠囊中制成 . ?硬膠囊呈圓筒形 ?由上下配套的兩節(jié)緊密套合而成 ?其大小用號碼表示，可根據(jù)藥物劑量大小而選用 . (2)軟膠囊劑： 系將一定量的藥物（或藥材提取物）溶于適當(dāng)液體輔料中，然后封閉于軟膠囊中而成的一種圓形或橢圓形制劑 . 根據(jù)制備方法不同，軟膠囊劑又可分兩種： 有縫膠丸： 用壓制法制成，中間往往有壓縫； 無縫膠丸： 用滴制法制成，呈圓球形而無縫 . 二、膠囊劑的制備 制備空膠囊、填充物料 填充 封口 (一 )硬膠囊制備 根據(jù)制備方法：
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