細胞的增殖和調(diào)控ppt課件-文庫吧資料
2025-03-27 21:44本頁面
【正文】 組成：感受器、信號傳導通路、效應器。G1 phase fuse with M phase MPF founds phase fuse with M phaseG2 phase fuse with M phaseMPFManfred Lohka and Jim Maller (UCHSC) used cell free assay to purify MPF tested various cytosolic fractions for MPF activityMPF is a 2 subunit protein kinase 32 kDa and 45 kDaMPFCdkn History of MPFPCC Mphase Trigger MPFP32 and P45,kinase 非洲爪蟾 (1988)Cdc gene found in yeast P34cdc2 trigger G2/M P34cdc2 bind with P56cdc13 active Cyclin found in urchin, key factorFor Mphase(1983) MPF include Cdk and cyclin p32=P34cdc2=CDKP45 = P56cdc13 = cyclin B Cyclin n 1983 first foundn G1phase: cyclin C, cyclin D, cyclin E Cln1, Cln2, Cln3(Yeast)Mphase: cyclin A, cyclin B,Comparatively stableA2Destroy box Cyclin boxB1PEST, G1 cyclin renewal C Different Cyclin expressed in different cell cycle phaseBind with Different CDK,regulate CDK kinase activity特點：在細胞周期中呈周期性變化。– G2期 PCC為雙線染色體，說明 DNA復制已完成。– G1期 PCC為單線狀，因 DNA未復制。– M期又稱 D期 (mitosis or division)，細胞分裂開始到結(jié)束。– S期 (synthesis phase)，指 DNA復制的時期。Mathematical Biosciences Institute (Ohio State Univ), 2 October 2022
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