偽狂犬病的控制和清除-文庫吧資料
2024-12-14 07:25本頁面
【正文】 gD can protect pigs 對(duì) gB, gC 或 gD 抗體可保護(hù)豬 Immunity to Pseudorabies Local Immunity 局部免疫 Humoral Immunity 激素免疫 Cellular Immunity 細(xì)胞免疫 Interferon 干擾素 Prevention of Latency (occupy sites) 預(yù)防潛伏感染 Antibody titers are no measure of protection (Kit, et al. 1994, Boersma et al. 1998) 抗體滴度不能衡量保護(hù)能力 Pseudorabies Vaccination 偽狂犬病的免疫 Vaccination Does Not Produce Absolute Protection 免疫不能提供絕對(duì)的保護(hù) Vaccinated Pigs can still get the Infection 免疫后的豬仍可感染 Vaccinated Pigs can still Produce Virus 免疫后的豬可產(chǎn)生病毒 Vaccinated Pigs can still Get Sick 免疫后的豬可發(fā)病 Vaccination is Useful, and is CostEffective 免疫有用，且合算 Pseudorabies Vaccination Can: 免疫能： Reduce Likelyhood of Infection 減少感染可能性 Reduce Severity and Length of Illness if pig is infected 萬一豬感染，可縮短病程，減弱病情 Reduce Length of Time that Virus is Produced (4x) 縮短病毒產(chǎn)生時(shí)間 Reduce Amount of Virus that is Produced (1000x) 減少產(chǎn)生的病毒量 Reduce Likelyhood of Latent Infection 減少潛伏感染機(jī)會(huì) Reduce Likelyhood of Recrudescence 減少反復(fù)感染機(jī)會(huì) 6 8 10 12 14 16 周 偽狂犬病免疫模型 Maternal Antibody 母源抗體 Piglets very well protected at least until after weaning. 至少可為仔豬提供到斷奶前的保護(hù) Generally protection is weak by week 8 12, and piglet may bee infected. 8－ 12周齡前保護(hù)力減弱，豬可能感染 Significant Potential Interference with Immunization. 對(duì)疫苗有明顯潛在干擾 Late vaccination (1016 weeks) gives highest Ab response, but may be too late for protection. 10－ 16周齡免疫可產(chǎn)生高抗體反應(yīng)，但來不及提供保護(hù) Intranasal vaccination circumvents maternal Ab. 鼻腔免疫接種避開母源抗體 All maternal PRV Ab disappears by 16 weeks of age. 母源抗體到 16周齡前消失 Pigs receiving colostrum from infected sows will be gE Positive for up to 16 weeks of age. 吃到感染母豬初乳的仔豬 16周齡前是 gE陽性 Maternal Antibody has a halflife of about 10 days. 母源抗體的半衰期大約 10天 Maternal Ab for diseases like Strep, Mycoplasma, APP only lasts 3 4 weeks. Parvovirus maternal Ab may last as long as 6 months. PRRS Ab lasts up to 8 weeks but only protective for about 3 weeks or less. 對(duì)鏈球菌，支原體，豬放線桿菌的母源抗體可持續(xù) 3－ 4周，細(xì)小病毒母源抗體持續(xù) 6個(gè)月，藍(lán)耳病的母源抗體可持續(xù) 8周，但只能保護(hù)到 3周齡或更小。PSEUDORABIES Control and Eradication 偽狂犬病的控制和清除 朱穩(wěn)森 美國(guó)谷物協(xié)會(huì) 廣州 Pseudorabies 偽狂犬病 PRV 偽狂犬病病毒 Aujeskys Disease (AD) 奧葉斯基病 Infectious Bulbar Paralysis 感染性延髓麻痹 Historical Records report disease in Cattle in early 1800s 早在 1800年有報(bào)道該病發(fā)生于牛 All species of mammals susceptible. 哺乳動(dòng)物易感 Cats, Dogs, Sheep, Cattle, Horses, Rats, Monkeys. Man is resistant. Rare reports in Humans (Skin rash). 人有抵抗性，人感染的報(bào)道很少見（皮疹） PRV was often confused with swine fever.
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