【正文】
這些結(jié)果提供了令人信服的分子機(jī)制,以支持臨床觀察表明GS可能有一個(gè)有利的影響的一些骨關(guān)節(jié)炎患者的關(guān)節(jié)軟骨損失的預(yù)防。16756968.)(Chu SC, Yang SF, Lue KH et al. (October 2006). Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clinica Chimica Acta。16334942)(Uitterlinden EJ, Jahr H, Koevoet JL et al. (March 2006). Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society 14 (3): 250–7. doi:12801482.) the stimulation of the synthesis of proteoglycans,[50] and the decrease in catabolic activity of chondrocytes inhibiting the synthesis of proteolytic enzymes and other substances that contribute to damage cartilage matrix and cause death of articular chondrocytes.[51][52][53][54]蛋白多糖合成的刺激,和抑制蛋白水解酶和其他有助于損傷軟骨基質(zhì),造成關(guān)節(jié)軟骨細(xì)胞死亡的物質(zhì)的合成以減少軟骨細(xì)胞的分解代謝活動。.)(Chan PS, Caron JP, Orth MW (July 2006). Shortterm gene expression changes in cartilage explants stimulated with interleukin