measles麻疹ppt課件(參考版)
2025-01-22 19:28本頁面
【正文】 scarlet fever。 roseola intantum。 and in the conjunctivae, ect Resulting In 1) Koplik spots and skin rash: serous exudation and proliferation of endothelial cells of the capillaries, vasculitis 2) Conjunctivis PATHOGENESIS AND PATHOLOGY 3) Laryngitis, croup, bronchitis :general inflammatory reaction 4) Hyperplasia of lymphoid tissue: multinucleated giant cells (WarthinFinkeldey reticuloendothelial giant cells) may be found 5) Interstitial pneumonitis: Hecht giant cell pneumonia. 6) Bronchopneumonia: due to secondary bacterial infections 7) Encephalomyelitis: perivascular demyelinization occurs in areas of the brain and spinal cord. 8) Subacute sclerosing panencephalitis(SSPE): degeneration of the cortex and white matter with intranuclear and intracytoplasmic inclusion bodies CLINICAL MANIFESTATION Typical Manifestation: patients havn’t had measles immunization, or vaccine failure with normal immunity or those havn’t used immune globulin 1. Incubation period (infection to symptoms) : 618days (average 10 days) 2. Prodromal period: ? 34 days ? Nonspecific symptoms: fever, malaise, anorexia, headache ? Classical triad: cough, coryza, conjunctivitis (with photophobia, lacrimation) CLINICAL MANIFESTATION Enanthem (Koplik spots): ? Pathognomonic for measles ? 2448 hr before rash appears ? 1mm, grayish white dots with slight, reddish areolae ? Buccal mucosa, opposite the lower 2nd molars ? fade soon after rash onset CLINICAL MANIFESTATION Koplik spots CLINICAL MANIFESTATION 3. Rash period 34days Exanthem: Erythematous, nonpruritic, maculopapular ? Upper lateral of the neck, behind ears, hairline, face ? trunk ? arms and legs ? The severity of the disease is directly related to the extent and confluence of the rash , CLINICAL MANIFESTATION CLINICAL MANIFESTATION CLINICAL MANIFESTATION CLINICAL MANIFESTATION Temperature: ? Rises abruptly as the rash appears ? Reaches 40℃ or higher ? Settles after 45 days – if persists, suspect secondary infection Coryza, fever, and cough: ? Increasingly s
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