止血障礙血栓形成ppt課件(參考版)
2025-01-08 12:19本頁面
【正文】 antibody is to beta 2 glycoprotein 1 and platelet phospholipids in patients with lupus anticoagulants (aPTT and/or PT). Thrombus ? Size, shape and morphology Mural thrombus Infected thrombus – bacterial endocarditis Verrucous thrombus – LibmanSacks endocarditis Thrombus ? Natural history: – Resolution – Propagation – Fragmentation/embolization – Organization Resolution Propagation – plete occlusion F Fragmentation and Embolization Organization – Fibroblast proliferation Organization – Endothelial cell differentiation Resolution Organization Rethrombosis Thrombus ? Clinical presentation: Arterial – coronary, carotid and femoral ? Acute MI, Angina ? CVA, TIA ? Claudication Venous – superficial veins, deep veins Thrombophlebitis, swollen, painful extremity Pulmonary embolus 。 12% of population ? Increased risk of venous thrombosis 2x Protein C Deficiency ? Autosomal dominant ? Mutation results in mild to severe deficiency。Disorders of Hemostasis: Thrombosis John Lazarchick, . Director, Hematopathology/He
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