理學生理學ppt課件(參考版)
2025-01-06 00:42本頁面
【正文】 Cl 分泌 NKCC cotransporter CFTR Na+ channel 基底膜面 頂膜面 ? New born CFTR?/? and CFTRΔF508/ΔF508 pigs increased nasal Vt and ?Vtamil like persons who have CF. But have no more Na+ absorption than controls. ? In CF, elevations in basal Vt, basal Isc, ?Vtamil, and ?Iscamil are caused by the lack of apical Cl? conductance, not by increased Na+ conductance. ? Measured Gt, Isc, and Vt. Hypothesis ? How lack of CFTR changes Electrolyte transport in primary cultures of differentiated human Airway epithelia? ? Decreased Cl? conductance, increased Na+ conductance, or a bination of the two? Materials and Methods ? Primary Cultures of Human Airway Epithelia. ? In vitro Human Airway Epithelia. ? Electrophysiological Measurements. Results ? The effects of these pounds on CF and NonCF Epithelia: ? Observations about Gt: . Na+ channel activity increased in CF epithelia ? Amiloride sensitive current in epithelia Na+ absorption in CF not exceed that in nonCF. Opencircuit
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