偽狂犬病的控制和清除(參考版)
2024-12-11 07:25本頁面
【正文】 Spleen 肝臟和脾臟的壞死性病灶 Enteric Lesions 腸道病變 Differential Diagnosis 鑒別診斷 Swine Influenza 豬流感 Parvovirus 細(xì)小病毒 Circoviral “Shaker Pig Disease” 環(huán)狀病毒性豬震顫病 Classical Swine Fever 經(jīng)典型豬瘟 PRRS 藍(lán)耳病 Enterovirus 腸病毒 Confirmed Diagnosis 明確診斷 Virus Isolation 病毒分離 Fluorescent Antibody Tissue Section 熒光抗體組織切片 Serology 血清學(xué) Serum Neutralization (SN) Reliable, gives serum titer 血清中和反應(yīng)（ SN）－ 可靠，給出滴度 ELISA Sensitive, specific, Differential ELISA－ 靈敏，特異性強(qiáng)，區(qū)別明顯 Latex Agglutination (LAT) Very sensitive, can give false positive (dilute 1:40 may help) 膠乳凝集反應(yīng)－靈敏，可能假陽性（稀釋 40倍好些） PCR, InSitu Hybridization, Etc. PCR， 原位雜交，等 6 8 10 12 14 16 18 20 22 24 周 偽狂犬病免疫模型 x x x x x A G E24222022161412108642REVSN1 . 0.9.8.7.6.5.4.3.2.10 . 00 1 感染母豬 感染仔豬 陽性 陰性 2 4 6 8 10 12 14 16 18 20 22 24 抗 體 水 平 周齡 偽狂犬病 gE (gI) ELISA gE (gI) Economic Loss due to Pseudorabies 偽狂犬病帶來的經(jīng)濟(jì)損失 Losses due to Acute Outbreaks 急性爆發(fā)的損失 Reproduction Problems 繁殖障礙 Piglet Mortality 仔豬死亡率 Chronic Form 慢性型 Pneumonia 肺炎 Immunosuppression 免疫抑制 Losses in Growing/Finishing up to $12 USD/pig 生長肥育階段的損失可達(dá) 12美元 /頭豬 Cost of Vaccination 疫苗成本 Lost Access to Markets 市場的損失 024681012141618支原體 支原體 + 偽狂犬病 Interaction of PRV and Mycoplasma Infection 支原體與偽狂犬病的互作 A G E24222022161412108642REVSN1 . 0.9.8.7.6.5.4.3.2.10 . 00 1 感染母豬 感染仔豬 陽性 陰性 2 4 6 8 10 12 14 16 18 20 22 24 抗 體 水 平 周齡 偽狂犬病 gE (gI) ELISA gE (gI) Major Genes of Pseudorabies Virus 偽狂犬病病毒的主要基因 gE (gI) Deletion renders virus avirulent. 缺失后失去毒力 Reliable ELISA, PCR differential testing. ELISA， PCR可用于鑒別檢測 gG (gX) Common deletion in vaccine. 疫苗中通常缺失 Differential ELISA less distinct than for gE ELISA的鑒別檢測結(jié)果不如對 gE效果好 Major Genes of Pseudorabies Virus TK (thymidine kinase) 胸腺嘧啶激酶 Popular safety deletion 常見安全缺失 Deletion inhibits virus replication 缺失抑制病毒復(fù)制 gI (gp63) Sometimes deleted to reduce virulence 缺失可減弱毒力 Not very important in immunization. 在免疫作用中不重要 Major Genes of Pseudorabies Virus gB (gII) Useful in induction of protective immunity 益于產(chǎn)生保護(hù)性免疫力 gC (gIII) Sometimes deleted. Differential Elisa Available 有時(shí)缺失，可用 ELISA鑒別 gD (gp50) gD controls ability of virus to perate cells. gD important in Immunization. 控制病毒對細(xì)胞的穿透能力，對免疫重要 Antibody against gB, gC or
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