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44(2):22642. ? Perinatal HIV guidelines working group members. Public Health Task Force Remendations for use of antiretroviral drugs in pregnant HIV1 infected women for maternal health and interventions to reduce perinatal HIV1 transmission. In the US. AIDS treatment information services (ATIS): current treatment guidelines. Updated February 4, 2020. Link to Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy Updated November 26, 2020. Available at . 。285:1186. ? Levine AM. Evaluation and management of HIVinfected women. Ann Intern Med. 2020 。來自 料庫下載 Preventing Mother to Child Transmission of HIV Raymond Powrie, MD Associate Professor Medicine and Obstetrics and Gynecology Brown University Women and Infants Hospital of Rhode Island Instructor Harvard Medical School 來自 料庫下載 HIV and Pregnancy General Principles ? Reproductive decisions in HIVinfected women seem to be no different than those in HIVnegative women ? HIV infection does not effect obstetrical outes ? Pregnancy does not effect course of HIV disease 來自 料庫下載 HIV and Pregnancy General principles ? Ideal management of pregnancy in HIV infected women includes: – good prenatal care with a multidisciplinary team – maximizing antiretroviral and prophylactic therapies in the mother, and – observation for evidence of disease progression 來自 料庫下載 HIV Screening in Pregnancy ? All women of childbearing age should be encouraged to be tested for HIV 來自 料庫下載 Mother to Child Transmission of HIV ? In the absence of effective antiretroviral treatment in the mother, there is a ~25% risk of transmission to the newborn. – can occur at any stage in gestation – most transmission occurs during labor and delivery through direct contact of the infant with maternal blood and cervical secretions 來自 料庫下載 Antiretroviral therapy in pregnancy: ZDV ? Use of ZDV in the mother during pregnancy and in the neonate postpartum decreases the rate of vertical transmission of HIV from 25% to 8% ? Long term follow up of infants exposed to ZDV in utero has not demonstrated any adverse effects. 來自 料庫下載 PACTG 076 protocol ? Maternal Prescription During Second and Third Trimesters – Ad