analysisandevaluationoftheevidenceofdiagnostictest(英文版)-wenkub.com
2025-03-08 08:51 本頁面
【正文】 2023年 3月 29日星期三 8時(shí) 50分 44秒 08:50:4429 March 2023 1一個(gè)人即使已登上頂峰，也仍要自強(qiáng)不息。勝人者有力，自勝者強(qiáng)。 , March 29, 2023 閱讀一切好書如同和過去最杰出的人談話。 2023年 3月 29日星期三 上午 8時(shí) 50分 44秒 08:50: 1楚塞三湘接，荊門九派通。 08:50:4408:50:4408:503/29/2023 8:50:44 AM 1成功就是日復(fù)一日那一點(diǎn)點(diǎn)小小努力的積累。 2023年 3月 上午 8時(shí) 50分 :50March 29, 2023 1行動(dòng)出成果，工作出財(cái)富。 :50:4408:50Mar2329Mar23 1故人江海別，幾度隔山川。Analysis and evaluation of the evidence of diagnostic test Clinical Trail Study Center Cao Sumei Diagnostic test are not just about diagnosis ? Screening ? Determining severity ? Optimally therapy ? Prognosis ? Monitor Example ? Carotid ultrasound can tell you the severity of the patient’s carotid stenosis ? Carotid ultrasound can tell you the patient’s prognosis for stroke and death ? Carotid ultrasound can predict your patient’s likely responsiveness to therapy Basic principles of conducting diagnostic studies ? Apply the gold standard to determine whether or not the target condition is present ? Gold standard: The most recognized standard for clinician to diagnose the target condition ?Pathological measurement ?Operation finding ?Special imaging detection ?Longterm followup ?Recognized standard What if your test is more gold than the standard ? May lead to underestimate of the diagnostic power of the evaluating ? One strategy for dealing with this problem is to use longterm followup as a gold standard To Whom Should the Gold Standard Be Applied? ?to everyone ?selective performing the gold standard on patients may result in “ verification bias ” or “workup bias” Recruit your participants ? Recruit the targetnegative and targetpositive participants identified by gold standard ? characteristic of those to whom you will want to apply the test in clinical practice ? Including a broad spectrum of the diseased ?case： from mildly to severely ?control： a broad spectrum of peting conditions ? An alternative approach is that recruiting a consecutive sample of patients Measurement procedures ? Specifying test technique ? Reproducibility ? Blinding of the individual conducting or interpreting the test to the gold standard Select statistical procedure ?Calculating sample si
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