【正文】
發(fā)現(xiàn)的 30種 conc是依靠病毒的 vonc探針找到的;并不是所有 conc都有對(duì)應(yīng)的同源 vonc。s disease and Parkinson39。s disease ? Spinal cord injuries ? Blood diseases, including leukemias ? Burns 5. Stem cell plasticity Adult stem cells can differentiate into a large number of different cell types. Turning blood into brain: Science, 2022, 290: 17791782 Turning brain into blood: Science, 1999, 283: 534535 NSC+EGF amp。 vsrc缺失 3/4不能致癌的 RSV,注入雞體內(nèi),發(fā)現(xiàn)缺失的 vsrc與 csrc發(fā)生重組, vsrc回復(fù)并致癌。 不影響病毒復(fù)制,但影響細(xì)胞轉(zhuǎn)化 1976年發(fā)現(xiàn),正常雞細(xì)胞核 DNA中,具有與 Vonc的同源序列,稱正常細(xì)胞中的同源序列為原癌基因( protooncogene) ,或 Concogene. vonc和 conc的關(guān)系 : conc來自 vonc. 理由如下 : vonc對(duì)病毒復(fù)制和生存都是不必要的;而 conc對(duì)細(xì)胞重要功能和活動(dòng)不可缺少;提示 conc是進(jìn)化中保存下來的細(xì)胞重要結(jié)構(gòu)元件。Cell differentiation and Cancer cells Cell differentiation Chapter 12 1. About the concept of cell differentiation The process that a cell changes to carry out a specialized function: Marked by: Morphology / Structure / Function ?The different cell types of a multicellular anism contain the same DNA. ?A cell can change the expression of its genes in response to external signals. ?Differences in mRNA expression patterns among different cell types. ?Different cell types synthesize different sets of proteins. ?Gene expression can be regulated at many of the st