20xx年醫(yī)學(xué)專題—第7章白細(xì)胞分化抗原及cam-資料下載頁
2024-11-16 00:29本頁面
【正文】 controlled migration of leukocyte populations.,第四十頁，共四十六頁。,The first step is usually a selectincarbohydrate interaction similar to that seen with neutrophil adhesion. Naive lymphocytes initially bind to HEVs by Lselectin, which serves as a homing receptor that directs the lymphocytes to particular tissues expressing a corresponding mucinlike vascular addressin such as CD34 or GlyCAM1.,第四十一頁，共四十六頁。,In the second step, an integrinactivating stimulus is mediated by chemokines that are either localized on the endothelial surface or secreted locally.,第四十二頁，共四十六頁。,Chemokine binding to Gprotein–coupled receptors on the lymphocyte leads to activation of integrin molecules on the membrane, as occurs in neutrophil extravasation. Once activated, the integrin molecules interact with Igsuperfamily adhesion molecules (e.g., ICAM1), so the lymphocyte adheres firmly to the endothelium. The molecular mechanisms involved in the final step, transendothelial migration, are poorly understood.,第四十三頁，共四十六頁。,第四十四頁，共四十六頁。,Steps in extravasation of a naive T cell through a high endothelial venule into a lymph node. Extravasation of lymphocytes includes the same basic steps as neutrophil extravasation but some of the celladhesion molecules differ. Activation of the integrin LFA1, induced by chemokine binding to the lymphocyte, leads to firm adhesion followed by migration between the endothelial cells into the tissue.,第四十五頁，共四十六頁。,內(nèi)容(n232。ir243。ng)總結(jié),Chap.7 白細(xì)胞分化抗原和黏附分子(fēnzǐ)。IgG3,1,2,4。白細(xì)胞粘附受體組（b2組）。血小板糖蛋白組（b3組）。ICAM1,2,3。Effector functions,第四十六頁，共四十六
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