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【正文】 atterns of gene expression found on microarray analysis were validated by RTPCR? results in our Chinese patients were also validated with use of a set of published NSCLC microarray data from patients from a Western population with NSCLC? propose who have tumors with a highrisk gene signature could benefit from Cisplatinbased adjuvant chemotherapy, those with a lowrisk gene signature could be spared largescale, multicenter studies are necessary to test this idea? STAT1 ?arrested growth and apoptosis in many types of cancer cells by inducing expression of p21WAF1 and caspase.? MMD ? expressed in mature macrophages, macrophage activation promotes cancer metastasis, BUT function of MMD protein is unknown? DUSP6 ? inactivates extracellular signalregulated kinase 2 (ERK2) (also known as mitogenactivated protein kinase 1 [MAPK1]), resulting in tumor suppression and apoptosis? ERBB3 ? member of epidermal growth factor receptor family of tyrosine kinases, can shorten cell survival? LCK ? member of the Src family of protein tyrosine kinases, is expressed mainly in T cells and is one of first signaling molecules downstream of the Tcell receptor, a key role not only in differentiation and activation of T cells but also in induction of apoptosis 。 LCK is expressed in many cancers and regulates mobility of cancer cells? 5Gene can predict clinical oute in patients with surgically resected NSCLC. ? This signature could be useful in stratifying patients according to risk in trials of adjuvant treatment of the diseaseThank you for your attention!!!
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