【正文】 ine, R. A parison of the inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by nine different macrolide antibiotics. Curr. Microbiol. 1998, 37: 41241742. Champney, .。 Tober, . Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics. Curr. Microbiol. 1998, 37: 41842543. Pereyre, S.。 Guyot, C.。 Renaudin, H.。 Charron, A.。 B233。b233。ar, C. and B233。b233。ar, . In Vitro Selection and Characterization of Resistance to Macrolides and Related Antibiotics in Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 2004, 48: 46046544. Pereyre, S.。 Gonzalez, P.。 Barbeyrac, B.。 Darnige, A.。 Renaudin, H.。 Charron, A.。 Raherison, S.。 B233。b233。ar, C. and B233。b233。ar, . Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in . Agents Chemother. 2002, 46: 3142315045. Chambaud, I.。 Heilig, R.。 Ferris, S.。 Barbe, V.。 Samson, D.。 Galisson, F.。 Moszer, I.。 Dybvig, K.。 Wroblewski, H.。 Viari, A.。 Rocha, . and Blanchard, A. The plete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Res. 2001, 29: 2145–215346. Ter Laak, .。 Pijpers, A.。 Noordergraaf, .。 Schoevers, . and Verheijden, . Comparison of methods for in vitro testing of susceptibility of porcine Mycoplasma species to antimicrobial agents. Antimicrob. Agents Chemother. 1991, 35: 228–23347. GautierBouchardon, .。 Reinhardt, .。 Kobisch, M. and Kempf, I. In vitro development of resistance to enrofloxacin, erythromycin, tylosin, tiamulin and oxytetracycline in Mycoplasma gallisepticum, Mycoplasma iowae and Mycoplasma synoviae. Vet. Microbiol. 2002, 88: 47–5848. Stemke, .。 Huang, Y.。 Laigret, F. and Bov233。, . Cloning the ribosomal RNA operons of Mycoplasma flocculare and parison with those of Mycoplasma hyopneumoniae. Microbiol. 1994, 140: 857–86049. Furneri, .。 Rappazzo, G.。 Musumarra, .。 Tempera, G. and Roccasalva, . Genetic basis of natural resistance to erythromycin in Mycoplasma hominis. J. Antimicrob. Chemother. 2000, 45: 547–54850. Lucier, .。 Heitzman, K.。 Liu, , and Hu, . Transition Mutations in the 23S rRNA of erythromycinresistant isolates of Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 1995, 39 : 2770277351. Okazaki, N.。 Narita, M.。 Yamoda, S.。 lzumikawa, K.。 Umetsu, M.。 Kenri, T.。 Sasaki, Y.。 Arakawa, Y. and Sasaki, T. Characteristics of macrolideresistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro. Microbiol. Immunol. 2001, 45: 61762052. Matsuoka, M.。 Narita, M.。 Okazaki, N.。 Ohya, H.。 Yamazaki, T.。 Ouchi, K.。 Suzuki, I.。 Andoh, T.。 Kenri, T.。 Sasaki, Y.。 Horino, A.。 Shintani, M.。 Arakawa, Y. and Sasaki, T. Characterization and Molecular Analysis of MacrolideResistant Mycoplasma pneumoniae Clinical Isolates Obtained in Japan. Antimicrob. Agents Chemother. 2004, 48: 4624–463053. Furneri, .。 Rappazzo, G.。 Musumarra, .。 Pietro, .。 Catania, . and Roccasalva, . Two new point mutations at A2062 associated with resistance to 16membered macrolide antibiotics in mutant strains of mycoplasma hominis. Antimicrob. Agents Chemother. 2001, 45 : 2958296054. Kiser, .。 Popken, F. and Clemente J. The development of resistance to spiramycin, streptomycin and chlortetracycline by Mycoplasma gallisepticum in chick embryos. Avian , 5: 283～29155. Zanella, A.。 Martino, .。 Pratelli, A. and Stonfer, M. Development of antibiotic resistance in Mycoplasma gallisepticum in vitro. Avian Pathol. 1998, 27: 59159656. Takahashi, I.。 Yoshida, T.。 Higashide, Y. and Sawada, T. In vitro resistance acquisition in Mycoplasma gallisepticum against ofloxacin, tylosin and spectinomycin. Japanese J. Antibiot. 2002, 55: 29130157. 李凌凌，張部昌，馬清鈞. 紅霉素抗菌作用及細菌產(chǎn)生紅霉素抗性的機制. 國外醫(yī)藥抗生素分冊. 2004, 25(1): 12,3358. Arthur, M.。 Molinas, C.。 Mabilat, C. and Courvalin, P. Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob. Agents Chemother. 1990, 34: 2024–202659. Paulsen, .。 Nguyen, L.。 Sliwinski, .。 Rabus, R. and Saier, . Microbial genome analyses: parative transport capabilities in eighteen prokaryotes. J. Mol. Biol. 2000, 301: 75–100.60. Blanchard, B.。 Saillard, C.。 Kobisch M.。 and Bov233。, . Analysis of putative ABC transporter genes in Mycoplasma hyopneumoniae. Microbiol. 1996, 142: 18551862