【導讀】該傳感器是完全植入的，并且每秒傳送一次壓力數(shù)據(jù)，壓力檢測評估范圍。為psi，分辨率為psi。在體外，設備的校準測量表現(xiàn)出高度的線性度和。良好的時間響應。該裝置植入一些豬的體內進行研究，歷時超過3天。不在的發(fā)展遠程醫(yī)療和遠程病人監(jiān)控平臺的第一步。例如，在重癥監(jiān)護病。房，血壓監(jiān)測可用動脈線進行連續(xù)監(jiān)測。它的局限性是高度可變的準確性，患者往往服用鎮(zhèn)靜。劑，以防止因運動對自身造成傷害。另一方面，在標準的基礎護理中，雖然對。連續(xù)點的測量通常采取每2-12小時一次。重要的生命體征測量值間的顯影可能。目前，還沒有連續(xù)監(jiān)測生命體征的，并且可提供無極端入侵和或麻煩。束縛的患者，使他們脫離了大醫(yī)院的監(jiān)控，他們可以參加醫(yī)院無線傳感器網(wǎng)絡，儲和處理，進而可能會提升監(jiān)控效率?？傮w積最小化，因為電池通常是最大的組成部分。并進行8分鐘固化，以防止任何鉑銥電線或wirebonds破壞連接。

　　

【正文】 er by the battery or DC power source. The LabVIEW program ran on the puter and stored the wireless pressure data. The pressure was incrementally stepped up from 0– psi to test the required pressure range and held at each step for 5 min with pressure readings taken every 2 min. To test the resolution of the device, the incremental pressure changes were psi from 0– psi and psi for – psi. At the conclusion of each test, a calibration curve was generated that related the voltage recorded on the puter to the pressure inside the chamber. Another test of the packaged device was performed by submerging it in a gal bucket of dyed water and left to transmit data until the battery drained out. Afterwards, the data was analyzed to look for any signs of short circuits, characterize any sensor drift, and quantify the full lifetime of the device. The packaging was later removed to look for any signs of water leakage. In vivo tests Adult female swine were used for in vivo testing as approved by UCLA Medical Center IRB 202018511. One device was implanted into the bladder and another was placed inside the peritoneal cavity as a reference. The tips of the catheter leads were placed in those spaces while the sensor nodes were placed in a subcutaneous pocket. Following surgery, the pigs were kept in a holding pen in a vivarium while the puter and radio receiver were set up outside the pen to collect the data. At this point, the pigs were fully conscious and ambulatory. After 2–4 days, the pigs were sacrificed and the devices were explanted. A brief necropsy was performed to look for tissue inflammation or any immune response to the silicone packaging. The devices were later inspected for any damage, leaking, or any other failure points if necessary. 3 Results amp。 discussion Testing of the fully assembled lead and sensor node showed a rapid and linear response ( psi/V) of the sensor. When the device was disassembled and reassembled following the initial tests, the offset was observed to change slightly. Once the device was fully packaged and ready to be implanted, this change was pensated by paring the calculated pressure from the calibration curve and the actual pressure from a pressure gauge and adjusting the offset value on the calibration curve. While testing the integrity of the PDMS packaging, the device performed without malfunction until the battery drained for a lifetime of 107 h. The output voltage stayed constant for the initial days with a variance of . However, for the next 2 days, the voltage steadily decreased until the device ceased functioning. An inspection of the device once it had ceased functioning showed no liquid or gaseous water or water perated the PDMS layer and the data was free of short circuits. 4 Conclusion In summary, we have constructed a fully implantable wireless in vivo pressure sensor for use in short term urological studies and patient monitoring. In vitro testing demonstrates its quick temporal response and its high linearity. Through in vivo tests in the bladder and peritoneal cavity of porcine models, the pressure sensing system was able to successfully record medically relevant data, which contained physiological events like urination. This platform can be expanded with additional sensing modalities, such as a thermistor for core temperature, platinum and silver electrodes for blood or tissue oxygen tension, and analysis of blood pressure to obtain heart rate if the lead was implanted into an artery. Further miniaturization of the catheter to a point such that it can fit inside a needle can eliminate the need for major surgery. While the electronics and wireless transmission unit were kept internally for this test because of fears of damage to it by the animal, for human applications, it may be more practical to keep it outside yet secured to the body. This would make deployment of a sensor platform like this more practical and ubiquitous within a hospital.