羥基的保護(hù)與去保護(hù)(編輯修改稿)
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【文章內(nèi)容簡(jiǎn)介】 was dried and concentrated in vacuo. The resulting material was then dissolved in dry DMF (20 mL) and treated at 0 oC with imidazole (816 mg, mmol), followed by chlorodimethylsilane (, ). The reaction mixture was stirred for 1h at 0oC and then diluted with EtOAc (200mL). The anic layer was washed with water and brine. Upon silica gel chromatography (10% ethyl acetate in hexane), g (90%) of the desired product 2 was obtained. J. , 61, 2065) Deprotection: Hydrolysis was carried out under aprotic conditionanhydrous tetrabutylammonium fluoride in THF solution. 方法 ： TBDMS保護(hù) 1. TBS醚的生成和斷裂的難易取決于空間因素，常用于對(duì)多 官能團(tuán)、位阻 丌同的分子進(jìn)行 選擇性保護(hù)。 (在伯、仲醇中， TBS 基相對(duì)來(lái)說(shuō)較易于與伯醇反應(yīng) ) 2. 在分子中羥基位阻丌大 時(shí) ,主要 通過(guò) TBSCl 對(duì)羥基進(jìn)行保護(hù)；當(dāng)羥基位阻較大 時(shí) ,則 采用較強(qiáng)的硅醚化試劑 TBSOTf 來(lái)實(shí)現(xiàn) 。 3. 相對(duì)來(lái)說(shuō)，產(chǎn)物醚對(duì)
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