【文章內(nèi)容簡(jiǎn)介】
gbu Medical College Ig Fc受體: ? CD64( FcgRI) (高親和力) ? CD32 ( FcgRII) (低親和力) ? CD16 ( FcgRIII) (低親和力) ? CD89 ( FcaR) (中等親和力) ? CD23( FceRII) (低親和力) 三、參與免疫效應(yīng)的的 CD分子 Department of Immunology, BBMC Department of Immunology Bengbu Medical College Department of Immunology, BBMC Department of Immunology Bengbu Medical College 細(xì)胞凋亡相關(guān) CD分子: ? CD95 (Fas/Apo1— 與細(xì)胞活化,細(xì)胞凋亡有關(guān)) ? CD178( Fas L) Department of Immunology, BBMC Department of Immunology Bengbu Medical College 四、 CD分子與臨床 ?參與疾病的發(fā)生 ,如: ?CD分子作為病毒受體; HIVCD4, EBVCD21 ?Fas分子缺陷:淋巴增殖病,自身免疫病 ?胰島素依賴性糖尿病, ? CD及其抗體與臨床免疫學(xué)診斷 ?白血病免疫學(xué)診斷( CD分子檢測(cè) ) ?免疫學(xué)細(xì)胞亞群檢測(cè)( T及其亞群, B, NK) ? CD及其抗體的臨床治療 ?抗 CD3單抗,(移植排斥) ?抗 CD19抗 CD20,( B細(xì)胞淋巴瘤) Department of Immunology, BBMC Department of Immunology Bengbu Medical College 第二節(jié) 細(xì)胞粘附分子 ( cell adhesion molecule, CAM / AM) —— 介導(dǎo)細(xì)胞之間,或細(xì)胞與細(xì)胞外基質(zhì)間相互接觸和結(jié)合的 膜表面糖蛋白質(zhì)。 —— 參與細(xì)胞的識(shí)別,活化,信號(hào)傳導(dǎo),分化以及 運(yùn)動(dòng)等過(guò)程 —— 據(jù)結(jié)構(gòu)劃分為五類: 選擇素 黏蛋白樣家族 整合素 免疫球蛋白超家族 鈣粘蛋白 Department of Immunology, BBMC Department of Immunology Bengbu Medical College Department of Immunology, BBMC Department of Immunology Bengbu Medical College 選擇素家族 ( selectin) 一類以細(xì)胞外多糖為配體的膜單肽分子, 介導(dǎo)白細(xì)胞與內(nèi)皮細(xì)胞或血小板的粘附。 選擇素 L( CD62L, 白細(xì)胞選擇素) 選擇素 E( CD62E, 內(nèi)皮細(xì)胞選擇素) 選擇素 P( CD62P, 血小板選擇素) 一、黏附分子的分類及其特性 Department of Immunology, BBMC Department of Immunology Bengbu Medical College Department of Immunology, BBMC Department of Immunology Bengbu Medical College Department of Immunology, BBMC Department of Immunology Bengbu Medical College Department of Immunology, BBMC Department of Immunology Bengbu Medical College Departme