分生緒論第一次ppt課件(編輯修改稿)
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【文章內(nèi)容簡(jiǎn)介】 ynthesis. 1975. (41y) (37y) Reverse transcription（引發(fā)癌癥的內(nèi)因） 22 One geneone enzyme Beadle Tatum 23 桑格 Sanger 吉爾伯特 Gilbert 伯格 Berg 1980 Sanger （英） Gilbert amp。 Berg（英） 酶法核苷酸測(cè)序的設(shè)計(jì)者 化學(xué)測(cè)序法的設(shè)計(jì)者 DNA重組，在細(xì)菌中表 達(dá)胰島素 DNA重組技術(shù)的元老 Sanger還由于測(cè)定了牛胰島素的一級(jí)結(jié)構(gòu)而獲得 1958年諾貝爾化學(xué)獎(jiǎng)。 24 1989 Altman （加）＆ Cech（美） Founder of Ribozyme（ 核酶 ） Sidney Altman Thomas R. Cech The Nobel Prize in Chemistry 1980 “For their contributions concerning the determination of base sequences in nucleic acids Walter Gilbert Frederick Sanger 1932 1918 1983. (86y) DNA transposable element The Nobel Prize in Chemistry 1989 “Ror their discovery of catalytic properties of RNA Ribozyme Sidney Altman Thomas R. Cech Yale University New Haven, CT, USA University of Colorado Boulder, CO, USA 1939 1947 The Nobel Prize in Chemistry 1993 Kary B. Mullis 1944 “For his invention of the polymerase chain reaction (PCR) method 1997， The Nobel Prize in Physiology or Medicine “For his discovery of Prions – a new biological principle of infection Stanley B. Prusiner Univ. of California, School of Medicine USA 1942 29 30 IV. The future of Medical molecular biology 31 ? Two major directions of the current medical molecular biology: （ 1） Constantly put the theory and techniques deepen. （ 2） Kept touch with and integrate with other subjects. 32 The four frontier research fields at present （ 1） Structural molecular biology （ 2） Human Genomic Project （ 3） Gene expression and regulation （ 4） Signal transduction 33 （ 1） Structural molecular biology Biological function depends on the structure. Only biomacromolecules have a specific space solid structure ,namely three dimensional structure ,can they have physical capabilities. 34 （ 2） Human Genomic Project The Human Genome Project (HGP) is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of iden
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