【正文】 ts in patients with rheumatoid arthritis: a metaanalysis of observational studies. Ann Rheum Dis. 2012 Sep。 RA增高的病死率很大部分歸因于心血管疾病( cardiovascular disease，CVD)。 RA患者中高血壓是普遍(pǔbi224。,Metsios GS et al. Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. Eur J Cardiovasc Prev Rehabil. 2009 Apr。 神經(jīng)酰胺能干擾血管內(nèi)皮細(xì)胞NO的合成以及降低NO的生物活性，損害血管舒張功能。guez L et al. Genetic markers of cardiovascular disease in rheumatoid arthritis. Mediators Inflamm. 2012。342:c7086. Goodson NJ et al. Nonsteroidal antiinflammatory drug use does not appear to be associated with increased cardiovascular mortality in patients with inflammatory polyarthritis: results from a primary care based inception cohort of patients. Ann Rheum Dis. 2009 Mar。63(4):5229. Singh JA et al. Tocilizumab for rheumatoid arthritis: a Cochrane systematic review. J Rheumatol. 2011 Jan。,RA患者(hu224。71(9):15249.。,Thank you for your attention!,第二十九頁(yè)，共三十頁(yè)。nzhě)CVD的處理,EULRA推薦(tuīji224。 TNF拮抗劑可能改善一些CV風(fēng)險(xiǎn)因素(yīn s249。,RA患者CVD危險(xiǎn)(wēixiǎn)因素,眾所周知，NSAIDs也包括環(huán)氧化酶2抑制劑增加高血壓和心肌梗死(xīn jī ɡěnɡ sǐ)風(fēng)險(xiǎn)。b236。,Vaudo G, et al. Endothelial dysfunction in young patients with rheumatoid arthritis and low di