【正文】 days Currently under way,第二十五頁，共四十四頁。,RCT of HVHF in Septic Shock,5919 ICU admissions,Oliguric ARF N=248,Nonoliguric ARF N=130,Not randomized in study N=142,Randomized In study N106,EHV n=35,ELV n=35,LLV n=36,Hemofiltration n=352,No hemofiltration N=6,Bouman CS et al. Effects of early highvolume CVVH on survival and recovery of renal function in IC patients with ARF. Crit Care Med 2002。,Dose and Timing of CVVH in ARF,Bouman CS, et al. Critical Care Med 2002。uqī)CRRT對危重病患者的影響 －早期或預防性CRRT可降低ARF患者病死率,Gettings LG. Intensive Care Med, 1999, 25: 805813,第十四頁，共四十四頁。 60: 1154 63 Kellum JA. Continuous versus intermittent RRT. A metaanalysis. Intensive Care Med 2002。 6 Days P = 0.001,N Engl J Med 2002。j236。,Retrospective cohort study Pats with ARF and required dialysis between April 1,1996, and March 31, 1999 2 ICU in Canada. N=261,CRRT對ARF腎功能恢復(huīf249。,Mode of RRT differences among continents,Bellomo, et al. 2001,Understanding Renal Replacement Therapy and Acute Renal Failure in the ICU (The B.E.S.T kidney study),第三頁，共四十四頁。i)壓下降，導致腎臟低灌注，加重腎臟缺血性損傷，延遲急性腎衰竭腎功能的恢復,為什么CRRT促進(c249。 2 days Everyotherday:16 177。 34: 424 432 Mehti. RL. Collaborative Group for Treatment of ARF in ICU:A RCT of continuous versus IHD for ARF. Kidney Int 2001。,1989－1997：100例創(chuàng)傷(chuāngshāng)后ARF 早期－后期的臨界：BUN 60mg/dl 兩組病人創(chuàng)傷評分、GCS、發(fā)生休克的比例、年齡、性別和創(chuàng)傷分布均無差異,早期－后期(h242。 2436 L/24 h),Bouman et al. Crit Care Med 30:22052211, 2002,第十六頁，共四十四頁。 356: 26 30,第十九頁，共四十四頁。 If hemodynamically unstable (SOFA CVS score: 34) CVVHDF at 20 ml/kg/hr or SLED 3times/week (target Kt/V = 1.21.4/session),第二十四頁，共四十四頁。nli224。)預后,第三十二頁，共四十四頁。ng)的可能途徑,1,2,第三十六頁，共四十四頁。)血流動力學的影響 Hemodynamic response to coupled plasmafiltrationadsorption in human septic shock,N=12 mechanically ventilated pats with septic shock Intervention: A median of 10 consecutive sessions (prescribed treatment time: 10 h/session。CRRT對ARF腎功能恢復的影響 －CRRT促進腎功能