msa多系統(tǒng)萎縮(更新版)
【正文】 pons ?Hypometabolism on PET in putamen Criteria for probable MSA ? A sporadic,progressive,adult(30y)onset disease characterized by ?Autonomic failure and ?Poorly levodoparesponsive parkinsonism or ?A cerebellar syndrome Criteria for definite MSA ? A sporadic,progressive,adult(30y)onset disease characterized by ?Neuropathologic ?Glial cytoplasmic inclusions with neurodegenerative changes in striatonigral or olivopontocerebellar structures. Company Logo Nonsupporting features ?Classic pillrolling rest tremor ?Clinically significant neuropathy ?Hallucinations not induced by drugs ?Onset before age 30y or after age 75y ?Family history of ataxia or parkinsonism ?Dementia ?White matter lesions suggesting multiple sclerosis Company Logo conclusion Possible MSA requires a sporadic, progressive adultonset disease including parkinsonism or cerebellar ataxia and at least one feature suggesting autonomic dysfunction plus one other feature that may be a clinical or a neuroimaging abnormality. Probable MSA requires a sporadic, progressive adultonset disorder including rigorously defined autonomic failure and poorly levodoparesponsive parkinsonism or cerebellar ataxia. Definite MSA requires neuropathologic demonstration of CNS αsynuclein–positive glial cytoplasmic inclusions with neurodegenerative changes in striatonigral or olivopontocerebellar structures. Company Logo Company Logo （四）鑒別診斷 ? ?伴有自主神經(jīng)功能不全的帕金森病的特點(diǎn)為嚴(yán)重的直立性低血壓 ,餐后低血壓 ,對(duì)去甲腎上腺素很敏感 ,為節(jié)后交感神經(jīng)病變 ,常在疾病的中晚期出現(xiàn)； MSA雖有帕金森樣癥狀 ,但以肢體僵直為主而少有震顫； MSA對(duì)多巴胺制劑反應(yīng)差。 Company Logo 四、治療 ?無特效治療方法 ,主要對(duì)癥治療 。 LOGO LOGO 謝謝觀看 /歡迎下載 BY FAITH I MEAN A VISION OF GOOD ONE CHERISHES AND THE ENTHUSIASM THAT PUSHES ONE TO SEEK ITS FULFILLMENT REGARDLESS OF OBSTACLES. BY FAITH I BY FAITH
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